口面部疼痛与睡眠之间的关系：英国生物数据库和全基因组关联研究数据分析

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2025-01-01 Epub Date: 2024-05-06 DOI:10.1016/j.jds.2024.04.027

Yang Jiang , Xu Gong , Min Yu , Xuemei Gao

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引用次数: 0

摘要

背景/目的口腔面部疼痛在牙科治疗中很常见。本研究旨在利用英国生物银行数据集探索口面部疼痛与睡眠之间的关系，并基于流行病学关联，利用全基因组关联研究数据调查因果关系。材料和方法首先，对来自UK Biobank的196,490名参与者进行了横断面研究。收集了疼痛状况和睡眠特征的信息。采用多变量模型探讨与比值比（OR）的关系。其次，采用孟德尔随机化分析方法对口面部疼痛进行数据分析，包括颞下颌关节紊乱相关疼痛（n = 377,277）和非典型面部疼痛（n = 331,749），以及睡眠特征，包括睡眠时间（n = 446,118）、短睡眠（n = 411,934）、长睡眠（n = 339,926）、打鼾（n = 359,916）、起床难易程度（n = 385,949）、失眠（n = 453,379）、白天打盹（n = 452,071）、白天打盹（n = 452,633）和睡眠类型（n = 403,195）。结果横断面研究证实了疼痛与睡眠之间的双向性。全身疼痛的参与者与不健康的睡眠模式有显著关联(OR = 1.18, P <；0.001)和其他睡眠特征(P <；0.05)。慢性口面部疼痛的风险与睡眠时间呈非线性关系（P = 0.032）。孟德尔随机化分析显示，长时间睡眠与颞下颌关节紊乱相关疼痛有因果关系（OR = 6.77, P = 0.006）。结论疼痛与睡眠的关系是双向的。人们发现长时间睡眠与慢性口面部疼痛有因果关系。

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Relationships between orofacial pain and sleep: Analysis of UK biobank and genome-wide association studies data

Background/purpose

Orofacial pain is common in dental practices. This study aimed to explore relationships between orofacial pain and sleep using the UK Biobank dataset and, based on epidemiological associations, to investigate the causal association using genome-wide association studies data.

Materials and methods

First, a cross-sectional study was conducted with 196,490 participants from UK Biobank. Information on pain conditions and sleep traits was collected. Multivariable models were used to explore the relationships with odds ratio (OR). Second, Mendelian randomization analyses were conducted using data for orofacial pain, including temporomandibular joint disorders-related pain (n = 377,277) and atypical facial pain (n = 331,749), and sleep traits, including sleep duration (n = 446,118), short sleep (n = 411,934), long sleep (n = 339,926), snoring (n = 359,916), ease of getting up (n = 385,949), insomnia (n = 453,379), daytime dozing (n = 452,071), daytime napping (n = 452,633), and chronotype (n = 403,195).

Results

The cross-sectional study confirmed the bidirectionality between pain and sleep. Participants experiencing pain all over the body showed a significant association with an unhealthy sleep pattern (OR = 1.18, P < 0.001) and other sleep traits (P < 0.05). Risks of chronic orofacial pain were associated with sleep duration in a non-linear relationship (P = 0.032). The Mendelian randomization analyses indicated that long sleep was causally associated with temporomandibular joint disorders-related pain (OR = 6.77, P = 0.006).

Conclusion

The relationship between pain and sleep is bidirectional. Long sleep is found to be causally associated with chronic orofacial pain.

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来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.