一例胸膜间皮瘤免疫组化染色呈 Krebs von den Lungen-6 阳性的病例

IF 0.8 Q4 RESPIRATORY SYSTEM

Respiratory Medicine Case Reports Pub Date : 2024-01-01 DOI:10.1016/j.rmcr.2024.102040

Yugo Matsumura , Seidai Sato , Keiko Haji , Takeshi Masuda , Hiroto Yoneda , Hirokazu Ogino , Hirohisa Ogawa , Masaki Hanibuchi , Noboru Hattori , Yasuhiko Nishioka

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引用次数: 0

摘要

一名 71 岁的男性到医院就诊，主诉是劳累性呼吸困难。胸部 CT 显示顶胸膜有多个结节性病变。胸腔镜胸膜活检诊断为上皮样型胸膜间皮瘤。最初开始化疗时，他的血清克雷布斯-冯-登肺-6（KL-6）水平较高。然而，化疗开始后，随着肿瘤的缩小，血清 KL-6 水平逐渐下降。免疫组化染色显示肿瘤细胞表达 KL-6。这是首次报道上皮型胸膜间皮瘤的肿瘤细胞直接产生KL-6。

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A case of pleural mesothelioma with immunohistochemical staining positive for Krebs von den Lungen-6

A 71-year-old male visited a hospital with a chief complaint of exertional dyspnea. A chest CT revealed multiple nodular lesions on the parietal pleura. Thoracoscopic pleural biopsy was performed resulting in a diagnosis of pleural mesothelioma with epithelioid type. When chemotherapy was initially initiated, his serum level of Krebs von den Lungen-6 (KL-6) was high. However, once chemotherapy was started, the serum KL-6 level gradually decreased with tumor shrinkage. Immunohistochemical staining revealed the expression of KL-6 from the tumor cells. This is the first report of KL-6 production directly from tumor cells in epithelial-type pleural mesothelioma.

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