全身氧化应激水平是近视性脉络膜新生血管的病理和预后因素之一

IF 3.2 Q1 OPHTHALMOLOGY
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引用次数: 0

摘要

目的 探讨全身氧化应激水平与近视脉络膜新生血管(mCNV)及其临床结果的关系。5岁)、30名高度近视(HM)但无mCNV的患者(平均年龄:59.6岁)的30只眼睛,以及23名HM和mCNV患者(平均年龄:61.8岁)的23只眼睛,这些患者在首次IVI后的6个月随访期间接受了玻璃体内抗血管内皮生长因子抗体注射(IVI)。主要结果指标临床特征和氧化应激参数。结果HM/mCNV组的BAP和B/d比值均明显低于HM/无mCNV组(分别为P = 0.002和P = 0.012)和对照组(分别为P = 0.001和P = 0.026)。在多重逻辑回归分析中,轴长(几率比 1.878,P = 0.042)和 B/d 比值(几率比 0.470,P = 0.026)与 mCNV 显著相关。将患者分为高 B/d 比值组和低 B/d 比值组(临界值为 5.2)后发现,低 B/d 比值组的眼底脉络膜厚度(SFCT)比高 B/d 比值组低(P = 0.002),IVI 治疗次数比高 B/d 比值组多(P = 0.029)。在多元回归分析中,只有 B/d 比率与 SFCT 显著相关(β = 0.684,P = 0.006)。测量HM患者的氧化应激参数可能有助于评估患mCNV的风险和确定疾病的活动性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Systemic Oxidative Stress Level as a Pathological and Prognostic Factor in Myopic Choroidal Neovascularization

Purpose

To investigate the association of systemic oxidative stress level with myopic choroidal neovascularization (mCNV) and its clinical outcomes.

Design

Retrospective case-control study.

Participants

This retrospective study included 52 eyes of 52 healthy participants (mean age: 62.5 years), 30 eyes of 30 patients (mean age: 59.6 years) with high myopia (HM) but without mCNV, and 23 eyes of 23 patients (mean age: 61.8 years) with HM and mCNV who received intravitreal anti-VEGF antibody injections (IVIs) using a pro re nata regimen during the 6-month follow-up after the first IVI.

Methods

Clinical findings, including oxidative stress parameters, such as diacron reactive oxygen metabolites (dROMs), biological antioxidant potential (BAP), and the BAP/dROM ratio (B/d ratio), were analyzed.

Main Outcome Measures

Clinical features and oxidative stress parameters.

Results

Both BAP and the B/d ratio were significantly lower in the HM/mCNV group than in the HM/no mCNV group (P = 0.002 and P = 0.012, respectively) and than in the control group (P = 0.001 and P = 0.026, respectively). In a multiple logistic regression analysis, axial length (odds ratio 1.878, P = 0.042) and the B/d ratio (odds ratio 0.470, P = 0.026) were significantly associated with mCNV. Dividing the patients into high and low B/d ratio groups (with a cutoff of 5.2) showed that subfoveal choroidal thickness (SFCT) was lower (P = 0.002) and the number of IVI treatments was higher (P = 0.029) in the low B/d ratio group than in the high B/d ratio group. In multiple regression analyses, only the B/d ratio was significantly associated with SFCT (β = 0.684, P = 0.006).

Conclusions

The oxidative stress level in eyes with HM differed according to mCNV, SFCT, and the number of IVI treatments. Measuring oxidative stress parameters might be useful in eyes with HM both for assessing the risk of developing mCNV and determining disease activity.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

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来源期刊
Ophthalmology science
Ophthalmology science Ophthalmology
CiteScore
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