口腔颌面重建中从实验室到临床转化的生物工程

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Ola M. Maria , Ashraf Heram , Simon D. Tran
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引用次数: 0

摘要

背景口腔颌面部重建中使用的传统技术主要侧重于利用自体组织,毫无疑问,自体组织改善了全球许多患者的功能和美观。然而,其成功与否取决于无数因素,例如:供体和受体部位的条件、患者的病史、外科医生的经验、高质量自体组织或干细胞的限制性供应以及手术成本和时间的增加。结果在过去几年中,生物医学工程已从实验室发展到临床应用,用于替代因创伤、癌症、先天性或后天性疾病而受损的身体组织。结论本综述对生物医学工程在唾液腺、口腔粘膜、牙科结构和颌面部重建方面的内容、益处、最新进展、局限性和未来预期进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bioengineering from the laboratory to clinical translation in oral and maxillofacial reconstruction

Background

Conventional techniques used in oral and maxillofacial reconstruction focus mainly on utilizing autologous tissues that have unquestionably improved function and esthetics for many patients, worldwide. However, the success depends on countless factors such as: donor and recipient sites conditions, patient’s medical history, surgeon’s experience, restricted availability of high-quality autogenous tissues or stem cells, and increased surgical cost and time.

Materials and Methods

Lately, teaming researchers, scientists, surgeons, and engineers, to address these limitations, have allowed tremendous progress in recombinant protein therapy, cell-based therapy, and gene therapy.

Results

Over the past few years, biomedical engineering has been evolving from the laboratory to clinical applications, for replacement of damaged body tissues due to trauma, cancer, congenital or acquired disorders.

Conclusions

This review provides an outlook on the content, benefits, recent advances, limitations, and future expectations of biomedical engineering for salivary glands, oral mucosa, dental structures, and maxillofacial reconstruction.

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来源期刊
Saudi Dental Journal
Saudi Dental Journal DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.60
自引率
0.00%
发文量
86
审稿时长
22 weeks
期刊介绍: Saudi Dental Journal is an English language, peer-reviewed scholarly publication in the area of dentistry. Saudi Dental Journal publishes original research and reviews on, but not limited to: • dental disease • clinical trials • dental equipment • new and experimental techniques • epidemiology and oral health • restorative dentistry • periodontology • endodontology • prosthodontics • paediatric dentistry • orthodontics and dental education Saudi Dental Journal is the official publication of the Saudi Dental Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.
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