{"title":"口腔颌面重建中从实验室到临床转化的生物工程","authors":"Ola M. Maria , Ashraf Heram , Simon D. Tran","doi":"10.1016/j.sdentj.2024.05.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Conventional techniques used in oral and maxillofacial reconstruction focus mainly on utilizing autologous tissues that have unquestionably improved function and esthetics for many patients, worldwide. However, the success depends on countless factors such as: donor and recipient sites conditions, patient’s medical history, surgeon’s experience, restricted availability of high-quality autogenous tissues or stem cells, and increased surgical cost and time.</p></div><div><h3>Materials and Methods</h3><p>Lately, teaming researchers, scientists, surgeons, and engineers, to address these limitations, have allowed tremendous progress in recombinant protein therapy, cell-based therapy, and gene therapy.</p></div><div><h3>Results</h3><p>Over the past few years, biomedical engineering has been evolving from the laboratory to clinical applications, for replacement of damaged body tissues due to trauma, cancer, congenital or acquired disorders.</p></div><div><h3>Conclusions</h3><p>This review provides an outlook on the content, benefits, recent advances, limitations, and future expectations of biomedical engineering for salivary glands, oral mucosa, dental structures, and maxillofacial reconstruction.</p></div>","PeriodicalId":47246,"journal":{"name":"Saudi Dental Journal","volume":"36 7","pages":"Pages 955-962"},"PeriodicalIF":1.7000,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1013905224001500/pdfft?md5=63ff3f3c3d61fcfec06e241b157427c2&pid=1-s2.0-S1013905224001500-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Bioengineering from the laboratory to clinical translation in oral and maxillofacial reconstruction\",\"authors\":\"Ola M. Maria , Ashraf Heram , Simon D. Tran\",\"doi\":\"10.1016/j.sdentj.2024.05.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Conventional techniques used in oral and maxillofacial reconstruction focus mainly on utilizing autologous tissues that have unquestionably improved function and esthetics for many patients, worldwide. However, the success depends on countless factors such as: donor and recipient sites conditions, patient’s medical history, surgeon’s experience, restricted availability of high-quality autogenous tissues or stem cells, and increased surgical cost and time.</p></div><div><h3>Materials and Methods</h3><p>Lately, teaming researchers, scientists, surgeons, and engineers, to address these limitations, have allowed tremendous progress in recombinant protein therapy, cell-based therapy, and gene therapy.</p></div><div><h3>Results</h3><p>Over the past few years, biomedical engineering has been evolving from the laboratory to clinical applications, for replacement of damaged body tissues due to trauma, cancer, congenital or acquired disorders.</p></div><div><h3>Conclusions</h3><p>This review provides an outlook on the content, benefits, recent advances, limitations, and future expectations of biomedical engineering for salivary glands, oral mucosa, dental structures, and maxillofacial reconstruction.</p></div>\",\"PeriodicalId\":47246,\"journal\":{\"name\":\"Saudi Dental Journal\",\"volume\":\"36 7\",\"pages\":\"Pages 955-962\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1013905224001500/pdfft?md5=63ff3f3c3d61fcfec06e241b157427c2&pid=1-s2.0-S1013905224001500-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Saudi Dental Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1013905224001500\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Saudi Dental Journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1013905224001500","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Bioengineering from the laboratory to clinical translation in oral and maxillofacial reconstruction
Background
Conventional techniques used in oral and maxillofacial reconstruction focus mainly on utilizing autologous tissues that have unquestionably improved function and esthetics for many patients, worldwide. However, the success depends on countless factors such as: donor and recipient sites conditions, patient’s medical history, surgeon’s experience, restricted availability of high-quality autogenous tissues or stem cells, and increased surgical cost and time.
Materials and Methods
Lately, teaming researchers, scientists, surgeons, and engineers, to address these limitations, have allowed tremendous progress in recombinant protein therapy, cell-based therapy, and gene therapy.
Results
Over the past few years, biomedical engineering has been evolving from the laboratory to clinical applications, for replacement of damaged body tissues due to trauma, cancer, congenital or acquired disorders.
Conclusions
This review provides an outlook on the content, benefits, recent advances, limitations, and future expectations of biomedical engineering for salivary glands, oral mucosa, dental structures, and maxillofacial reconstruction.
期刊介绍:
Saudi Dental Journal is an English language, peer-reviewed scholarly publication in the area of dentistry. Saudi Dental Journal publishes original research and reviews on, but not limited to: • dental disease • clinical trials • dental equipment • new and experimental techniques • epidemiology and oral health • restorative dentistry • periodontology • endodontology • prosthodontics • paediatric dentistry • orthodontics and dental education Saudi Dental Journal is the official publication of the Saudi Dental Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.