{"title":"利用生物信息分析研究脑出血","authors":"","doi":"10.1016/j.hest.2024.05.002","DOIUrl":null,"url":null,"abstract":"<div><p>The integration of bioinformatics analysis into intracerebral hemorrhage (ICH)research represents a paradigm shift in our approach to understanding, diagnosing, and treating this complex neurological disorder. By leveraging the power of bioinformatics, the scientific community is poised to make significant strides in combating this devastating condition, ultimately improving patient outcomes and quality of life. This study provides a comprehensive overview of the application of bioinformatics tools and techniques in elucidating the genetic, molecular, and environmental underpinnings of ICH. Through a detailed examination of genomic sequencing, transcriptomics, proteomics, and machine learning, we explore how these bioinformatics approaches have contributed to identifying genetic variants, understanding molecular pathways, and discovering biomarkers related to ICH. Challenges such as data complexity, integration of multi-omics data, and the translation of bioinformatics findings into clinical practice are discussed, alongside ethical considerations surrounding data privacy and patient consent. This study underscores the critical role of bioinformatics in advancing our understanding of ICH, offering insights into its pathophysiology, and paving the way for personalized medicine and targeted therapeutic interventions.</p></div>","PeriodicalId":33969,"journal":{"name":"Brain Hemorrhages","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589238X24000433/pdfft?md5=6150f307dd64af01d6fe7fdc9b9ac9c7&pid=1-s2.0-S2589238X24000433-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The use of bioinformatic analysis to study intracerebral hemorrhage\",\"authors\":\"\",\"doi\":\"10.1016/j.hest.2024.05.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The integration of bioinformatics analysis into intracerebral hemorrhage (ICH)research represents a paradigm shift in our approach to understanding, diagnosing, and treating this complex neurological disorder. By leveraging the power of bioinformatics, the scientific community is poised to make significant strides in combating this devastating condition, ultimately improving patient outcomes and quality of life. This study provides a comprehensive overview of the application of bioinformatics tools and techniques in elucidating the genetic, molecular, and environmental underpinnings of ICH. Through a detailed examination of genomic sequencing, transcriptomics, proteomics, and machine learning, we explore how these bioinformatics approaches have contributed to identifying genetic variants, understanding molecular pathways, and discovering biomarkers related to ICH. Challenges such as data complexity, integration of multi-omics data, and the translation of bioinformatics findings into clinical practice are discussed, alongside ethical considerations surrounding data privacy and patient consent. This study underscores the critical role of bioinformatics in advancing our understanding of ICH, offering insights into its pathophysiology, and paving the way for personalized medicine and targeted therapeutic interventions.</p></div>\",\"PeriodicalId\":33969,\"journal\":{\"name\":\"Brain Hemorrhages\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2589238X24000433/pdfft?md5=6150f307dd64af01d6fe7fdc9b9ac9c7&pid=1-s2.0-S2589238X24000433-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain Hemorrhages\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2589238X24000433\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Hemorrhages","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589238X24000433","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
将生物信息学分析融入脑出血(ICH)研究,代表着我们在理解、诊断和治疗这种复杂神经系统疾病的方法上发生了范式转变。通过利用生物信息学的力量,科学界有望在抗击这一毁灭性疾病方面取得重大进展,最终改善患者的预后和生活质量。本研究全面概述了生物信息学工具和技术在阐明 ICH 遗传、分子和环境基础方面的应用。通过对基因组测序、转录组学、蛋白质组学和机器学习的详细研究,我们探讨了这些生物信息学方法如何有助于识别基因变异、了解分子通路以及发现与 ICH 相关的生物标志物。我们还讨论了数据复杂性、多组学数据整合、将生物信息学发现转化为临床实践等挑战,以及围绕数据隐私和患者同意的伦理考虑。这项研究强调了生物信息学在促进我们对 ICH 的了解、提供对其病理生理学的见解以及为个性化医疗和靶向治疗干预铺平道路方面的关键作用。
The use of bioinformatic analysis to study intracerebral hemorrhage
The integration of bioinformatics analysis into intracerebral hemorrhage (ICH)research represents a paradigm shift in our approach to understanding, diagnosing, and treating this complex neurological disorder. By leveraging the power of bioinformatics, the scientific community is poised to make significant strides in combating this devastating condition, ultimately improving patient outcomes and quality of life. This study provides a comprehensive overview of the application of bioinformatics tools and techniques in elucidating the genetic, molecular, and environmental underpinnings of ICH. Through a detailed examination of genomic sequencing, transcriptomics, proteomics, and machine learning, we explore how these bioinformatics approaches have contributed to identifying genetic variants, understanding molecular pathways, and discovering biomarkers related to ICH. Challenges such as data complexity, integration of multi-omics data, and the translation of bioinformatics findings into clinical practice are discussed, alongside ethical considerations surrounding data privacy and patient consent. This study underscores the critical role of bioinformatics in advancing our understanding of ICH, offering insights into its pathophysiology, and paving the way for personalized medicine and targeted therapeutic interventions.