摘要 ED10-01：PI3K 的过去、现在和未来

IF 3.4 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

ACS Chemical Health & Safety Pub Date : 2024-05-02 DOI:10.1158/1538-7445.sabcs23-ed10-01

N. Vasan

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引用次数: 0

摘要

长期以来，PI3K 通路一直是发现癌症药物的沃土，包括雌激素受体阳性的转移性乳腺癌。由于存在靶向毒性，它也一直是难以有效用药的途径。克服这些毒性的新策略体现在新的药物类型和患者管理策略上。在此，我将讨论信号传导和肿瘤发生中的 PI3K 通路、目前抑制 PI3K 的疗法、限制疗效的机制以及增加 PI3K 治疗窗口期，重点是突变选择性 PI3K 抑制剂。最后，我将阐述 PI3K 领域的转化前景，重点介绍生物标志物发现、肿瘤相关性分析和患者权益维护方面的进展。引用格式：N. Vasan.PI3K 的过去、现在和未来 [摘要]。In：2023 年圣安东尼奥乳腺癌研讨会论文集；2023 年 12 月 5-9 日；德克萨斯州圣安东尼奥。费城（宾夕法尼亚州）：AACR; Cancer Res 2024;84(9 Suppl):Abstract nr ED10-01.

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Abstract ED10-01: PI3K past, present, and future

The PI3K pathway has long remained a fertile ground for drug discovery in cancer, including in estrogen receptor positive metastatic breast cancer. It has also remained a pathway difficult to drug effectively due to on target toxicities. New strategies to overcome these toxicities have manifested in novel drug types and management strategies for patients. Here I discuss the PI3K pathway in signaling and oncogenesis, current therapies inhibiting PI3K, mechanisms limiting efficacy, and increasing the PI3K therapeutic window with a focus on mutant selective PI3K inhibitors. Finally, I will expound on the translational future of the PI3K field, highlighting advances in biomarker discovery, tumor correlative analysis, and patient advocacy. Citation Format: N. Vasan. PI3K past, present, and future [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr ED10-01.

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来源期刊

ACS Chemical Health & Safety PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.10

自引率

20.00%

发文量

期刊介绍： The Journal of Chemical Health and Safety focuses on news, information, and ideas relating to issues and advances in chemical health and safety. The Journal of Chemical Health and Safety covers up-to-the minute, in-depth views of safety issues ranging from OSHA and EPA regulations to the safe handling of hazardous waste, from the latest innovations in effective chemical hygiene practices to the courts'' most recent rulings on safety-related lawsuits. The Journal of Chemical Health and Safety presents real-world information that health, safety and environmental professionals and others responsible for the safety of their workplaces can put to use right away, identifying potential and developing safety concerns before they do real harm.