摘要 PO4-07-07:基于吲哚菁绿荧光定量的乳腺癌前哨淋巴结转移预测模型的构建及其临床研究价值

IF 3.4 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Yang Wu, Wei Zhang, Jinhai Tang
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引用次数: 0

摘要

目的通过吲哚菁绿荧光定量分析建立乳腺癌前哨淋巴结转移预测模型。方法选择 2023 年 5 月至 2023 年 6 月在江苏省人民医院普外科接受改良根治性乳房切除术的 20 例乳腺癌患者进行研究分析。所有患者均采集了前哨淋巴结。采用皮下注射亚甲蓝和静脉注射吲哚菁绿的双重染色法对前哨淋巴结进行定位。术后病理结果是评估淋巴结有无转移癌的标准。同时,记录前哨淋巴结的经皮荧光,绘制荧光强度峰值时间曲线。为建立逻辑诊断预测模型和荧光阈值,在手术中切开前哨淋巴结,再次记录前哨淋巴结的荧光。ICG 阳性的判定标准由尤登指数决定,在逻辑诊断预测模型中,尤登指数用于判断阈值以上的淋巴结。低于 Logistic 诊断预测模型阈值的淋巴结是 ICG 阴性的判定标准。少于 3 个前哨淋巴结的病例被排除在外。结果最终选择了 19 个病例。亚甲蓝染色数据作为前哨淋巴结的判断标准。14例患者的荧光成像为100%,1例患者为66.7%(2/3),4例患者为125%-150%(5/4-6/4)。荧光定量值低于 2.91 为阴性淋巴结,高于 4.69 为阳性淋巴结。此外,在 2.91 和 4.69 之间需要谨慎。结合荧光动态衰减曲线,阳性组呈高原曲线,而阴性组大多呈下降曲线。将荧光定量与荧光动态衰减曲线相结合,与单纯荧光定量和荧光动态衰减曲线相比,阳性淋巴结的诊断率假阴性率更低。结论吲哚菁绿荧光血管造影的定量差值可用于预测乳腺癌前哨淋巴结的阳性转移,是前哨淋巴结活检的一种尝试。引用格式:吴洋,张伟,唐金海.基于吲哚菁绿荧光定量的乳腺癌前哨淋巴结转移预测模型的构建及临床研究价值[摘要].In:2023年圣安东尼奥乳腺癌研讨会论文集;2023年12月5-9日;德克萨斯州圣安东尼奥。费城(宾夕法尼亚州):AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO4-07-07.
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Abstract PO4-07-07: The construction and clinical research value of the prediction model of sentinel lymph node metastasis based on indocyanine green fluorescence quantification in breast cancer
Objective: To establish a prediction model of sentinel lymph node metastasis by quantitative indocyanine green fluorescence analysis in breast cancer. Methods: From May 2023 to June 2023, 20 patients with breast cancer underwent modified radical mastectomy in the General Surgery Department of Jiangsu Provincial People's Hospital were chosen for research and analysis. Sentinel lymph node were taken from all the patients. The sentinel lymph nodes were located by using the double staining method of subcutaneous injection of Methylene blue and intravenous injection of indocyanine green. The postoperative pathology is used as the standard for evaluating the presence or absence of metastatic cancer in lymph nodes. At the same time, the transcutaneous fluorescence of sentinel lymph node was recorded and the peak time of fluorescence intensity curve was plotted. To establish a logistic diagnostic prediction model and fluorescence threshold, the sentinel lymph node was incised during operation and the fluorescence of sentinel lymph node was recorded again. The criteria for ICG positive determination are determined by the Youden index, which was used to judge the lymph nodes above the threshold in the Logistic diagnostic prediction model. Lymph nodes below the threshold determined in the Logistic diagnostic prediction model are the criteria for ICG negative determination. Cases with less than 3 sentinel lymph node were excluded. Results: 19 cases were ultimately selected. Methylene blue staining data was taking as the judgment standard of sentinel lymph node. Fluorescence imaging was 100% in 14 patients, 66.7% (2/3) in 1 patient, and 125%-150% (5/4-6/4) in 4 patients. Fluorescence quantification values below 2.91 are negative lymph nodes, and values above 4.69 are positive lymph nodes. Moreover, caution is required between 2.91 and 4.69. Combining with the fluorescence dynamic attenuation curve, the positive group has a plateau curve, while the negative group mostly has a decline curve. Combining fluorescence quantification with fluorescence dynamic attenuation curve, the diagnostic rate of positive lymph nodes has a lower false negative rate compared to simple fluorescence quantification and fluorescence dynamic attenuation curve. Conclusion: The quantitative difference value of indocyanine green fluorescence angiography can be used to predict the positive metastasis of sentinel lymph node in breast cancer, making it an attempt to exempt sentinel lymph node biopsy. Citation Format: Yang Wu, Wei Zhang, Jinhai Tang. The construction and clinical research value of the prediction model of sentinel lymph node metastasis based on indocyanine green fluorescence quantification in breast cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO4-07-07.
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来源期刊
ACS Chemical Health & Safety
ACS Chemical Health & Safety PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
3.10
自引率
20.00%
发文量
63
期刊介绍: The Journal of Chemical Health and Safety focuses on news, information, and ideas relating to issues and advances in chemical health and safety. The Journal of Chemical Health and Safety covers up-to-the minute, in-depth views of safety issues ranging from OSHA and EPA regulations to the safe handling of hazardous waste, from the latest innovations in effective chemical hygiene practices to the courts'' most recent rulings on safety-related lawsuits. The Journal of Chemical Health and Safety presents real-world information that health, safety and environmental professionals and others responsible for the safety of their workplaces can put to use right away, identifying potential and developing safety concerns before they do real harm.
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