评估冠状动脉造影患者冠状动脉粥样硬化严重程度的无创动脉僵硬度指数

Kotaro Uchida, Lin Chen, Shintaro Minegishi, Takuya Sugawara, Rie Sasaki-Nakashima, Kentaro Arakawa, Hiroshi Doi, Tabito Kino, Naoki Tada, Sho Tarumi, Noriyuki Kawaura, K. Tamura, Kiyoshi Hibi, T. Ishigami
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引用次数: 0

摘要

在危及生命的心血管疾病发生之前对亚临床动脉粥样硬化进行早期诊断和适当治疗,是目前临床实践中尚未满足的主要医疗需求。无创动脉僵化指数、动脉速度-脉搏指数(AVI)和动脉压力-容积指数(API)与心血管疾病风险、传统动脉僵化指数和冠状动脉粥样硬化的严重程度有关。然而,很少有研究探讨这些指数与心血管事件发生之间的关系。我们测量了横滨市立大学医院在 2015 年 6 月至 2016 年 3 月期间接受心导管检查的 113 名连续患者的 AVI 和 API。患者随访至 2022 年 9 月,并评估了 CV 事件的发生情况。患者的平均年龄为 71.2 ± 10.7 岁,83 名患者(73.5%)为男性。共有 80 名患者(70.8%)患有高血压,87 名患者(77.0%)患有血脂异常,91 名患者(80.5%)有缺血性心脏病(IHD)病史。平均随访时间为 1752 ± 819 天。根据入组时冠状动脉造影(CAG)结果接受选择性经皮冠状动脉介入治疗(PCI)的患者的 API 明显高于未接受治疗的患者(38.5 ± 12.6,n = 17 vs. 31.3 ± 7.4,n = 96,p = 0.001)。在多重逻辑回归分析中,API与择期PCI的风险独立相关。总之,API 可以作为一个有用的指标,用于估计高 CV 风险患者是否需要进行冠状动脉介入治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Noninvasive Arterial Stiffness Index to Estimate the Severity of Coronary Atherosclerosis in Patients Undergoing Coronary Angiography
The early diagnosis and appropriate treatment of subclinical atherosclerosis before the onset of life-threatening cardiovascular (CV) diseases are major unmet medical needs in current clinical practice. Noninvasive arterial stiffness indices, the arterial velocity–pulse index (AVI) and the arterial pressure–volume index (API) have been associated with CV risks, conventional arterial stiffness indices, and the severity of coronary atherosclerosis. However, few studies have examined the relationship between these indices and the occurrence of CV events. We measured the AVI and API in 113 consecutive patients admitted to Yokohama City University Hospital for cardiac catheterization between June 2015 and March 2016. Patients were followed until September 2022, and the occurrence of CV events was assessed. The mean age was 71.2 ± 10.7 years, and 83 patients (73.5%) were male. In total, 80 patients (70.8%) had hypertension, 87 (77.0%) had dyslipidemia, and 91 (80.5%) had a history of ischemic heart disease (IHD). The mean follow-up duration was 1752 ± 819 days. Patients who received elective percutaneous coronary intervention (PCI) based on the results of coronary angiography (CAG) at the time of enrollment had significantly higher API than those who did not (38.5 ± 12.6, n = 17 vs. 31.3 ± 7.4, n = 96, p = 0.001). The API was independently associated with the risk of elective PCI in multiple logistic regression analysis. In conclusion, the API could be a useful indicator for estimating the need for coronary interventional treatment in patients with a high CV risk.
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