菠萝(Ananas comosus)可改善脂多糖诱发的大鼠抑郁样行为

Herlin Ajeng Nurrahma, A. Meliala, Nura Eky Vikawati, Paramita Narwidina, Irwan Supriyanto
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摘要

注射脂多糖(LPS)可通过增加吲哚胺 2,3-二氧酶的活性来减少色氨酸的供应,从而导致抑郁症和情绪障碍。色氨酸来自菠萝(Ananas cosmosus)等水果,对人体尤其是血清素能系统至关重要。 本研究旨在评估菠萝果肉(PP)如何对抗 LPS 诱导的雄性 Wistar 大鼠的抑郁行为。 实验将 30 只雄性 Wistar 大鼠分为 5 组,在腹腔注射 LPS(0.5 毫克/千克)前 28 天强制喂食菠萝果肉。I 组(正常)和 II 组(LPS 对照组)每天每公斤注射 15 毫升水。试验组 III、IV 和 V 分别给予不同剂量的 PP:低剂量(3.75 毫升/千克/天)、中剂量(7.5 毫升/千克/天)和高剂量(15 毫升/千克/天)。研究结束时,对大鼠进行开阔地试验(OFT)和尾悬试验(TST)。此外,还分析了血液和大脑样本中与抑郁有关的神经内分泌标记物。 LPS 会引发抑郁症状,具体表现为 TST 中不动时间的增加和 OFT 中焦虑行为的改变,尤其是在未接受 PP 的组别中。随后,与服用 PP 的组别相比,血浆和大脑中的血清素水平均有所下降。此外,观察到 LPS 组的皮质酮水平高于 PP 治疗组。以 7.5 毫升/千克/天的剂量连续注射 PP 28 天,可减轻 LPS 注射引起的抑郁效应。 聚丙烯可能具有抗抑郁特性,可减轻导致抑郁症状的行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pineapple (Ananas comosus) Ameliorates Depressant-like Behaviors in Rats Induced by Lipopolysaccharide
Lipopolysaccharide (LPS) injection can lead to depression and mood disorders by reducing tryptophan availability through increased activity of the enzyme indoleamine 2,3-dioxygenase. Tryptophan, sourced from fruits such as pineapple (Ananas cosmosus), is vital for the body, especially the serotonergic system. This study aims to assess how pineapple pulp (PP) counters LPS-induced depressive behaviors in male Wistar rats. The experiment involved force-feeding PP for 28 days before LPS injection (0.5 mg/kg intraperitoneal [i.p.]) in 30 male Wistar rats, divided into five groups. Groups I (normal) and II (LPS control) received 15 ml aquadest/kg/day. Test Groups III, IV, and V were given varied doses of PP; low dose (3.75 ml/kg/day), medium dose (7.5 ml/kg/day), and high dose (15 ml/kg/day). At the study's end, rats underwent the open field test (OFT) and the tail suspension test (TST). In addition, blood and brain samples were analyzed for neuroendocrine markers related to depression. LPS triggers depressive symptoms, as evidenced by increased immobility time in the TST and altered behaviors indicative of anxiety in the OFT, especially in groups not receiving PP. This is followed by decreased serotonin levels in both plasma and brain when compared to groups given PP. In addition, higher corticosterone levels were observed in the LPS group than in the PP-treated group. Administering PP at 7.5 ml/kg/day for 28 days can alleviate the depressive effects induced by LPS injection. PP may have antidepressant properties, potentially by mitigating behaviors leading to depressive symptoms.
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