早产儿视网膜病变与 10 岁时的神经发育结果和生活质量

Sudhir Sri, Elizabeth T. Jensen, Michael E. Msall, Joe Yi, Vasyl Zhabotynsky, Robert Joseph, Karl Kuban, Jean A. Frazier, Stephen Hooper, Hudson Santos, S. Gogcu, Jeffrey S Shenberger, Rebecca C Fry, T. O'Shea
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引用次数: 0

摘要

摘要 目的 在一组 10 岁的极早产儿中,我们评估了早产儿视网膜病变(ROP)严重程度的增加与不利的神经发育和生活质量结果的增加相关的假设。研究设计 根据早产儿视网膜病变的严重程度对研究对象进行分类。10岁时,对他们的神经认知能力、学习成绩和粗大运动功能进行评估,并对他们的自闭症谱系障碍、焦虑、抑郁和生活质量进行评估。结果 在对样本损耗和混杂因素进行调整后,只有与较低生活质量的关联仍然存在。视力障碍的严重程度越高,神经发育结果越差,生活质量越低。结论 在极早产儿中,视力损伤的严重程度(而非视网膜病变的严重程度)与 10 岁时的不良神经发育结果有关。严重的视网膜病变和更严重的视力损伤都与较低的生活质量有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Retinopathy of prematurity and neurodevelopmental outcome and quality of life at 10 years of age
Abstract Objective In a cohort of 10-year-old children born extremely preterm, we evaluated the hypothesis that increasing severity of retinopathy of prematurity (ROP) is associated with increasing frequency of unfavorable neurodevelopmental and quality of life outcomes. Study Design Study participants were classified according to the severity of ROP. At 10 years of age, their neurocognitive abilities, academic achievement, and gross motor function were assessed, and they were evaluated for autism spectrum disorder, anxiety, depression, and quality of life. Results After adjustment for sample attrition and confounders, only the association with lower quality of life persisted. Increasing severity of visual impairment was associated with worse neurodevelopmental outcomes and lower quality of life. Conclusion Among extremely preterm children, severity of visual impairment, but not severity of ROP, was associated with adverse neurodevelopmental outcomes at 10 years of age. Both severe ROP and more severe visual impairment were associated with lower quality of life.
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