Research Square

Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection.

Pub Date : 2026-02-12 DOI: 10.21203/rs.3.rs-2870695/v2 Joseph K Rathkey, Shannon S Choi, Vincent van Unen, Huimin Zhang, Min Liu, Jie Ding, Samira A Alwahabi, António J M Santos, Vamsee Mallajosyula, Joshua E Chan, Azam Mohsin, Maher M Elsheikh, Arjun Rustagi, Brandon Lam, Steven M Chirieleison, Bailey Wallen, Daniel Solis, Jordan Mah, Hudson T Horn, Katharina Röltgen, Ramesh Nair, Winston Trope, Alexander Guh-Siesel, Zhongqi Lin, Aimee Beck, Caitlin Edwards, Brock A Martin, James C Y Dunn, Joseph Shrager, Ralph A Baric, Benjamin Pinsky, Scott D Boyd, Catherine A Blish, Alessandro Sette, Alba Grifoni, Mark M Davis, Calvin J Kuo

Viral genome sequence datasets display pervasive evidence of strand-specific substitution biases that are best described using non-reversible nucleotide substitution models.

Pub Date : 2025-08-08 DOI: 10.21203/rs.3.rs-2407778/v2 Rita Sianga-Mete, Penelope Hartnady, Wimbai Caroline Mandikumba, Kayleigh Rutherford, Christopher Brian Currin, Florence Phelanyane, Sabina Stefan, Steven Weaver, Sergei L Kosakovsky Pond, Darren P Martin

Structure of METTL3-METTL14 with an m6A nucleotide reveals insights into m6A conversion and sensing.

Pub Date : 2024-10-23 DOI: 10.21203/rs.3.rs-3150186/v2 Shan Qi, Abhay Kumar, Shuang Chen, Shuo Zhou, Manish Parihar, Carmen Villalobos, Navom Gupta, Siu-Hong Chan, Manjeet K Rao, Stanton F McHardy, Shozeb Haider, Yogesh K Gupta