癌症治疗中的智能多功能纳米粒子：进展与展望》。

Q2 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical nanotechnology Pub Date : 2024-05-09 DOI:10.2174/0122117385304258240427054724

D. Karati, Swarupananda Mukherjee, Ayon Dutta, Dipanjana Ash, Shayeri Chatterjee Ganguly, Apurbaa Acharya, Biswajit Basu

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引用次数: 0

摘要

背景在全球范围内，癌症是第二大常见死因。化疗和其他传统的癌症治疗方法都有毒性，除了影响预定靶点外，还会影响正常细胞，因此有必要开发新型方法来增强细胞特异性靶向作用。方法本研究总结了纳米粒子在癌症治疗学方面的科学信息，以全面了解纳米粒子在癌症预防和治疗方面的潜力。本文检索了 Scopus、PubMed、Science Direct 和 Google Scholar 数据库，以纳米技术、癌症治疗学和聚合物为关键词，收集了近期（2015-2023 年）有关智能多功能纳米粒子的所有科学信息。结果纳米材料作为化学生物学工具在癌症治疗学中的应用得到了深入研究。纳米材料在稳定性、生物相容性和增强细胞渗透性等方面的用途得到了扩展，实现了精确靶向，改善了传统癌症治疗方法的弊端。纳米平台为获得多功能性和靶向技术提供了迷人的机会。智能纳米材料的生产，特别是纳米技术的出现，彻底改变了癌症的诊断和治疗。纳米粒子可以与多种生物基质（包括适配体、抗体、DNA 和 RNA）进行功能化，其宽广的表面积使其可以封装大量分子，从而提高了治疗效果。相对而言，由生物资源形成的纳米材料经济、易于生产且毒性较低，被认为比使用传统工艺制成的纳米材料更有益处。结论本研究强调了几种纳米粒子（NPs）的用途，并介绍了多种癌症治疗方法。此外，还对其在癌症治疗和诊断应用中的益处和困难进行了评论。根据本综述的研究结果，使用智能纳米材料可以大大推进癌症治疗学的发展，并为肿瘤检测和治疗开辟新的途径。

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Smart Multifunctional Nanoparticles in Cancer Theranostics: Progress and Prospect.

BACKGROUND Worldwide, cancer is the second most common cause of death. Chemotherapy and other traditional cancer treatments have toxicities that affect normal cells in addition to their intended targets, necessitating the development of novel approaches to enhance cell-specific targeting. METHODS The present work summarizes the scientific information on nanoparticles in cancer theranostics to provide a comprehensive insight into the preventive and therapeutic potential of nanoparticles in cancer. Scopus, PubMed, Science Direct, and Google Scholar databases are searched to collect all the recent (2015-2023) scientific information on smart multifunctional nanoparticles using the terms nanotechnology, cancer theranostics, and polymer. RESULTS The use of nanomaterials as chemical biology tools in cancer theranostics has been thoroughly investigated. They demonstrate expanded uses in terms of stability, biocompatibility, and enhanced cell permeability, enabling precision targeting and ameliorating the drawbacks of conventional cancer treatments. The nano platform presents a fascinating chance to acquire multifunctionality and targeting techniques. The production of smart nanomaterials, specifically with regard to the advent of nanotechnology, has revolutionized the diagnosis and treatment of cancer. The capability of nanoparticles to functionalize with a variety of biosubstrates, including aptamers, antibodies, DNA, and RNA, and their broad surface area allow them to encapsulate a huge number of molecules, contributing to their theranostic effect. Comparatively speaking, economical, easily produced, and less toxic nanomaterials formed from biological sources are thought to have benefits over those made using conventional processes. CONCLUSION The present study highlights the uses of several nanoparticles (NPs), and describes numerous cancer theranostics methodologies. The benefits and difficulties preventing their adoption in cancer treatment and diagnostic applications are also critically reviewed. The use of smart nanomaterials, according to this review's findings, can considerably advance cancer theranostics and open up new avenues for tumor detection and treatment.

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来源期刊

Pharmaceutical nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.20

自引率

0.00%

发文量

期刊介绍： Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.