香豆素衍生席夫碱金属复合物的合成及其对大肠杆菌的控制综述

IF 1.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Ankita Sharma, Sushma Devi, Sunil Kumar
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引用次数: 0

摘要

如今,抗菌菌株的耐药性问题已引起人们的极大关注。在细菌中,大肠埃希氏菌(Escherchia coli,E. coli)是主要的病原体,存在于人类和其他动物体内。它是各种严重疾病的罪魁祸首。阿莫西林、庆大霉素等多种常用抗生素和液体置换法是治疗大肠杆菌感染的建议疗法。一项研究证实,与常用的杂环类抗菌药相比,金属基杂环类药物具有不同的作用模式。香豆素是一种氧杂环化合物,是药物化学中的重要支架。香豆素衍生希夫碱的金属配合物具有广泛的药理活性。因此,在本综述文章中,我们重点讨论了香豆素衍生席夫碱的金属配合物及其各自的席夫碱配体的合成,以及它们对革兰氏阴性菌大肠杆菌的抗菌活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A review on synthesis of coumarin derived schiff’s base metal complexes and their control over E. coli bacterium
 Nowadays, the dilemma of drug resistance to antibacterial strains is of huge concern. Among the bacteria, Escherchia coli (E. coli) is the major pathogen, which is found in human and other animals. It is responsible for variety of severe diseases. A variety of commonly used antibiotics such as amoxicillin, gentamycin, etc and fluid replacement method are the suggested treatments for the infections caused by E. coli. In a study, it was established that the metal-based heterocyclic drugs demonstrated a different mode of action compared to the commonly used heterocyclic antibacterial drugs. Coumarin, an oxaheterocycle, is a privileged scaffold in medicinal chemistry. Metal complexes of coumarin-derived Schiff’s bases exhibit a broad range of pharmacological activities. Therefore, in the present review article, we have focused on the synthesis of metal complexes of coumarin derived Schiff’s bases as well as their respective Schiff’s base ligands and their antibacterial activities against the gram-negative bacterium E. coli.
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来源期刊
Main Group Chemistry
Main Group Chemistry 化学-化学综合
CiteScore
2.00
自引率
26.70%
发文量
65
审稿时长
>12 weeks
期刊介绍: Main Group Chemistry is intended to be a primary resource for all chemistry, engineering, biological, and materials researchers in both academia and in industry with an interest in the elements from the groups 1, 2, 12–18, lanthanides and actinides. The journal is committed to maintaining a high standard for its publications. This will be ensured by a rigorous peer-review process with most articles being reviewed by at least one editorial board member. Additionally, all manuscripts will be proofread and corrected by a dedicated copy editor located at the University of Kentucky.
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