增强手术前婴儿矫形器:新型氯己定合金纳米管改性聚甲基丙烯酸甲酯的特性、力学和生物膜抑制作用

IF 3 Q3 MATERIALS SCIENCE, BIOMATERIALS
Nadia Al Ansari, Mushriq F Abid
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引用次数: 0

摘要

研究目的这项体外研究旨在开发一种具有固有抗菌特性的新型纳米复合丙烯酸树脂。本研究评估了它对微生物生物膜形成的有效性,同时还评估了它的物理和机械性能。方法:聚甲基丙烯酸甲酯在聚甲基丙烯酸甲酯(PMMA)中加入四种不同浓度的洗必泰哈洛石纳米管(CHX-HNTs):按重量计分别为 1%、1.5%、3% 和 4.5%,同时加入对照组(CHX-HNTs 含量为 0)。利用微滴定生物膜试验评估了改性 CHX-HNTs 丙烯酸盐对白色念珠菌、金黄色葡萄球菌、肺炎链球菌和无乳链球菌的生物膜抑制能力。此外,还对每组的十个样品进行了抗折强度、表面粗糙度和硬度测试。统计分析采用单因素方差分析和 Tukey 检验进行比较(P<0.05)。结果CHX-HNTs 能有效减少白色念珠菌和细菌在 PMMA 上的粘附,其效果与剂量有关。CHX-HNTs 的浓度越高,微生物附着力的降低幅度越大,其中最高浓度(4.5 wt.%)的效果最显著,抑制率≥98%。与对照组相比,以任何测试浓度(1%、1.5%、3% 和 4.5 wt.%)添加 CHX-HNTs 都不会导致 PMMA 的抗弯强度、表面粗糙度或硬度出现任何统计学上的显著差异。结论CHX-HNT填料的新型整合作为一种有效的生物膜抑制剂,在丙烯酸器械上显示出良好的效果。这种新方法有可能在不对丙烯酸树脂的机械性能产生负面影响的情况下成功控制感染性疾病。临床意义。应全面评估将 CHX-HNTs 整合到手术前婴儿矫形器具中的效果,将其作为一种有希望减轻微生物感染的预防措施。这项评估在控制唇腭裂婴儿感染性疾病方面具有巨大潜力,从而为他们的整体健康做出宝贵贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enhancing Presurgical Infant Orthopedic Appliances: Characterization, Mechanics, and Biofilm Inhibition of a Novel Chlorhexidine-Halloysite Nanotube-Modified PMMA
Objectives. This in vitro study aimed to develop a novel nanocomposite acrylic resin with inherent antimicrobial properties. This study evaluated its effectiveness against microbial biofilm formation, while also assessing its physical and mechanical properties. Methods. Polymethylmethacrylate (PMMA) was modified with four different concentrations of chlorhexidine halloysite nanotubes (CHX-HNTs): 1%, 1.5%, 3%, and 4.5 wt.% by weight, along with a control group (0 wt.% CHX-HNTs). The biofilm inhibition ability of the modified CHX-HNTs acrylic against Candida albicans, Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus agalactiae was assessed using microtiter biofilm test. In addition, ten samples from each group were then tested for flexural strength, surface roughness, and hardness. Statistical analysis was performed using one-way ANOVA and Tukey’s test for comparison (P<0.05). Results. CHX-HNTs effectively reduced the adhesion of Candida albicans and bacteria to the PMMA in a dose-dependent manner. The higher the concentration of CHX-HNTs, the greater the reduction in microbial adhesion, with the highest concentration (4.5 wt.%) showing the most significant effect with inhibition rates ≥98%. The addition of CHX-HNTs at any tested concentration (1%, 1.5%, 3%, and 4.5 wt.%) did not cause any statistically significant difference in the flexural strength, surface roughness, or hardness of the PMMA compared to the control group. Conclusions. The novel integration of CHX-HNT fillers shows promising results as an effective biofilm inhibitor on acrylic appliances. This new approach has the potential to successfully control infectious diseases without negatively affecting the mechanical properties of the acrylic resin. Clinical Relevance. The integration of CHX-HNTs into presurgical infant orthopedic appliances should be thoroughly assessed as a promising preventive measure to mitigate microbial infections. This evaluation holds significant potential for controlling infectious diseases among infants with cleft lip and palate, thereby offering a valuable contribution to their overall well-being.
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来源期刊
International Journal of Biomaterials
International Journal of Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
4.30
自引率
3.20%
发文量
50
审稿时长
21 weeks
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