基于离子色谱法测定人体尿液中的锂,用于监测服药依从性

IF 1.3 Q4 CHEMISTRY, ANALYTICAL
N. Kwon, Jaehyeong Park, Seon Yeong Kim, B. Ko, J. Cheong, Jin Young Kim
{"title":"基于离子色谱法测定人体尿液中的锂,用于监测服药依从性","authors":"N. Kwon, Jaehyeong Park, Seon Yeong Kim, B. Ko, J. Cheong, Jin Young Kim","doi":"10.1002/sscp.202400057","DOIUrl":null,"url":null,"abstract":"Continuous Li monitoring is vital in ensuring the safety and treatment efficacy of probationers with psychotic disorders, such as bipolar disorder, depression, and mania. This study introduced a validated quantitative analysis method using ion chromatography (IC) to monitor Li+ concentration in urine. The methodology involved centrifuging the urine sample, diluting the supernatant with deionized water, and subsequent IC analysis using guard and analytical columns for precise Li+ concentration measurement. The method quantified Li+ within the range of 2–400 ng/mL, demonstrating its excellent linearity (r2 = 0.9983) with a weighting factor of 1/x. Precision levels below 12.8% were observed for both intraday and interday measurements with an accuracy of −5.9% to 15.2%. The detection limit was identified as 0.12 ng/mL. The method conformed to analytical standards in terms of selectivity, matrix effect, process efficiency, dilution integrity, and stability. Moreover, the method distinctly quantified Li+ while effectively eliminating interference from Na+, which had a similar retention time as Li+ with higher concentrations. Further, the developed method was successfully applied to analyze forensic urine samples of Li users, demonstrating its applicability for medication compliance monitoring using urine samples of mentally disordered probationers.","PeriodicalId":21639,"journal":{"name":"SEPARATION SCIENCE PLUS","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ion chromatography‐based determination of lithium in human urine for monitoring medication compliance\",\"authors\":\"N. Kwon, Jaehyeong Park, Seon Yeong Kim, B. Ko, J. Cheong, Jin Young Kim\",\"doi\":\"10.1002/sscp.202400057\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Continuous Li monitoring is vital in ensuring the safety and treatment efficacy of probationers with psychotic disorders, such as bipolar disorder, depression, and mania. This study introduced a validated quantitative analysis method using ion chromatography (IC) to monitor Li+ concentration in urine. The methodology involved centrifuging the urine sample, diluting the supernatant with deionized water, and subsequent IC analysis using guard and analytical columns for precise Li+ concentration measurement. The method quantified Li+ within the range of 2–400 ng/mL, demonstrating its excellent linearity (r2 = 0.9983) with a weighting factor of 1/x. Precision levels below 12.8% were observed for both intraday and interday measurements with an accuracy of −5.9% to 15.2%. The detection limit was identified as 0.12 ng/mL. The method conformed to analytical standards in terms of selectivity, matrix effect, process efficiency, dilution integrity, and stability. Moreover, the method distinctly quantified Li+ while effectively eliminating interference from Na+, which had a similar retention time as Li+ with higher concentrations. Further, the developed method was successfully applied to analyze forensic urine samples of Li users, demonstrating its applicability for medication compliance monitoring using urine samples of mentally disordered probationers.\",\"PeriodicalId\":21639,\"journal\":{\"name\":\"SEPARATION SCIENCE PLUS\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-05-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"SEPARATION SCIENCE PLUS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/sscp.202400057\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"SEPARATION SCIENCE PLUS","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/sscp.202400057","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0

摘要

持续的 Li 监测对于确保患有躁郁症、抑郁症和狂躁症等精神疾病的缓刑犯的安全和治疗效果至关重要。本研究采用离子色谱法(IC)监测尿液中 Li+ 的浓度,并引入了一种有效的定量分析方法。该方法包括离心尿液样本,用去离子水稀释上清液,然后使用保护柱和分析柱进行离子色谱分析,以精确测量 Li+ 浓度。该方法对 2-400 纳克/毫升范围内的 Li+ 进行了定量,在加权因子为 1/x 的情况下,线性关系良好(r2 = 0.9983)。日内和日间测量的精确度均低于 12.8%,准确度为 -5.9% 至 15.2%。检测限为 0.12 纳克/毫升。该方法在选择性、基质效应、过程效率、稀释完整性和稳定性方面均符合分析标准。此外,该方法在有效消除 Na+ 干扰的同时,对 Li+ 进行了明显的定量。此外,所开发的方法还成功地应用于分析李服用者的法医尿样,证明其适用于利用精神失常缓刑犯的尿样进行药物依从性监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ion chromatography‐based determination of lithium in human urine for monitoring medication compliance
Continuous Li monitoring is vital in ensuring the safety and treatment efficacy of probationers with psychotic disorders, such as bipolar disorder, depression, and mania. This study introduced a validated quantitative analysis method using ion chromatography (IC) to monitor Li+ concentration in urine. The methodology involved centrifuging the urine sample, diluting the supernatant with deionized water, and subsequent IC analysis using guard and analytical columns for precise Li+ concentration measurement. The method quantified Li+ within the range of 2–400 ng/mL, demonstrating its excellent linearity (r2 = 0.9983) with a weighting factor of 1/x. Precision levels below 12.8% were observed for both intraday and interday measurements with an accuracy of −5.9% to 15.2%. The detection limit was identified as 0.12 ng/mL. The method conformed to analytical standards in terms of selectivity, matrix effect, process efficiency, dilution integrity, and stability. Moreover, the method distinctly quantified Li+ while effectively eliminating interference from Na+, which had a similar retention time as Li+ with higher concentrations. Further, the developed method was successfully applied to analyze forensic urine samples of Li users, demonstrating its applicability for medication compliance monitoring using urine samples of mentally disordered probationers.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
SEPARATION SCIENCE PLUS
SEPARATION SCIENCE PLUS CHEMISTRY, ANALYTICAL-
CiteScore
1.90
自引率
9.10%
发文量
111
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信