抑郁症状与痴呆前脑脊液淀粉样病理无关

IF 1.4 Q4 CLINICAL NEUROLOGY

Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2024-05-10 DOI:10.1159/000539284

C. Eriksson, Bjørn-Eivind Kirsebom, Ragna Espenes, N. Siafarikas, K. Waterloo, A. Rongve, P. Selnes, Dag Aarsland, T. Fladby, Erik Hessen

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引用次数: 0

摘要

摘要：抑郁症状与阿尔茨海默病（AD）有关，但其神经生物学和神经心理学相关性仍鲜为人知。我们研究了抑郁症状是否与痴呆前期阿尔茨海默病的淀粉样蛋白（Aβ）病理和认知相关。方法：我们纳入了痴呆症起始队列中的主观认知功能减退（SCD，人数=160）和轻度认知功能障碍（MCI，人数=192）患者。抑郁症状采用老年抑郁量表（GDS-15）进行评估。通过脑脊液（CSF）Aβ42/40比值确定Aβ病理学。抑郁症状与认知能力之间的关系通过逻辑回归进行评估。结果：只有 Aβ 阴性 MCI 组（MCI-Aβ-）与抑郁症状相关（OR=2.65，p=.005）。抑郁症状与 MCI-Aβ- 组记忆力较差有关（OR=0.94，p=.039），但与 MCI-Aβ+ 组记忆力较好有关（OR=1.103，p=.001）。讨论：我们的研究结果表明，MCI患者的抑郁症状既与Aβ病理学无关，也与AD相关的记忆损伤无关。然而，非 AD MCI 患者的记忆损伤可能与抑郁症状有关。

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Depressive symptoms are not associated with predementia CSF amyloid pathology

ABSTRACT INTRODUCTION: Depressive symptoms are associated with Alzheimer’s disease (AD), but their neurobiological and neuropsychological correlates remain poorly understood. We investigate if depressive symptoms are associated with amyloid (Aβ) pathology and cognition in predementia AD. METHODS: We included Subjective Cognitive Decline (SCD, n= 160) and Mild Cognitive Impairment (MCI, n=192) from the Dementia Disease Initiation cohort. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS-15). Aβ pathology was determined using cerebrospinal fluid (CSF) Aβ42/40 ratio. Associations between depressive symptoms and cognition were assessed with logistic regression. RESULTS: Only the Aβ negative MCI group (MCI-Aβ-) was associated with depressive symptoms (OR=2.65, p=.005). Depressive symptoms were associated with worse memory in MCI-Aβ- (OR=0.94, p=.039), but with better performance in MCI-Aβ+ (OR=1.103, p=.001). DISCUSSION: Our results suggest that depressive symptoms in MCI are neither associated with Aβ pathology, nor AD-associated memory impairment. However, memory impairment in non-AD MCI may relate to depressive symptoms.

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来源期刊

Dementia and Geriatric Cognitive Disorders Extra Medicine-Psychiatry and Mental Health

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： This open access and online-only journal publishes original articles covering the entire spectrum of cognitive dysfunction such as Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field. Dementia and Geriatric Cognitive Disorders Extra provides additional contents based on reviewed and accepted submissions to the main journal Dementia and Geriatric Cognitive Disorders Extra .