Katharine Huynh, S. Jamadar, Julie Stout, K. Voigt, A. Lampit, N. Georgiou‐Karistianis
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引用次数: 0
摘要
亨廷顿氏病（Huntington's disease，HD）会导致认知能力逐渐下降，目前尚无治疗方法。计算机化认知训练（CCT）已在其他人群中显示出疗效，但其对亨廷顿氏病的效果在很大程度上还不为人所知。这项试点研究将探索计算机认知训练对 HD 的影响和神经机制。干预组参与者将完成为期 12 周的多领域 CCT 训练。对照组参与者将接受生活方式教育，并在研究结束后参加 CCT。主要结果是处理速度的变化。次要结果包括：其他认知领域的变化、大脑功能网络连接（通过核磁共振成像）和社会心理功能。可行性结果包括招募率、坚持率和保留率。这项研究可帮助人们深入了解 CCT 对 HD 的影响，并为未来的试验提供指导。临床试验注册：ACTRN12622000908730 ( ClinicalTrials.gov )
Effects and mechanisms of computerized cognitive training in Huntington's disease: protocol for a pilot study
Huntington's disease (HD) causes progressive cognitive decline, with no available treatments. Computerized cognitive training (CCT) has shown efficacy in other populations, but its effects in HD are largely unknown. This pilot study will explore the effects and neural mechanisms of CCT in HD. The intervention group participants will complete 12 weeks of multidomain CCT. Control group participants will receive lifestyle education and access to CCT after the study. The primary outcome is change in processing speed. Secondary outcomes include – change in other cognitive domains, functional brain network connectivity (derived from MRI) and psychosocial function. Feasibility outcomes include rates of recruitment, adherence and retention. This study may provide insights into the effects of CCT in HD and guide future trials. Clinical Trial Registration: ACTRN12622000908730 ( ClinicalTrials.gov )
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