自蔓延扁平原胞中成分多样性的自主发展

IF 3.1 Q2 CHEMISTRY, MULTIDISCIPLINARY
Irep Gözen, Stephen Mann, Aldo Jesorka
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引用次数: 0

摘要

本文介绍了自发生成成分多样的合成原细胞的实验途径。该途径由扁平巨型单拉美拉尔囊泡 (FGUV) 启动,这些囊泡来自成分不同的多拉美拉尔脂质库,并在固体表面自发扩散。在接触时,扩散的 FGUV 会合并,在融合界面上产生膜脂浓度梯度。随后,通过一系列的形状转换重建产生了一个由纳米管连接的脂质囊泡网络,这些囊泡继承了来自母体 FGUVs 双层膜的不同比例的膜成分。融合过程导致较小的 FGUV 被较大的 FGUV 吞噬,模仿捕食者与猎物的行为,在这种行为中,猎物的可观察到的特征会消失,但其成分会被捕食者 FGUV 带到下一代脂质囊泡中。我们推测,我们的研究结果可能为生命起源理论中的原生细胞自主多样化提供了一条可行的途径,并凸显了固体表面在早期地球上自然原生细胞的多样性发展和初级物种分化中可能扮演的角色。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Autonomous Development of Compositional Diversity in Self‐spreading Flat Protocells
An experimental pathway to the spontaneous generation of compositionally diverse synthetic protocells is presented. The pathway is initiated by flat giant unilamellar vesicles (FGUVs) that originate from compositionally different multilamellar lipid reservoirs and undergo spontaneous spreading across solid surfaces. On contact, the spreading FGUVs merge to produce a concentration gradient in membrane lipids across the fusion interface. Subsequent reconstruction through a series of shape transformations produces a network of nanotube‐connected lipid vesicles that inherit different ratios of the membrane constituents derived from the bilayers of the parent FGUVs. The fusion process leads to the engulfment of small FGUVs by larger FGUVs, mimicking predator‐prey behavior in which the observable characteristics of the prey are lost but the constituents are carried by the predator FGUV to the next generation of lipid vesicles. We speculate that our results could provide a feasible pathway to autonomous protocell diversification in origin of life theories and highlight the possible role of solid surfaces in the development of diversity and rudimentary speciation of natural protocells on the early Earth.
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