扩大的登革热综合征和非典型表现

Abdul Haseeb, Hareesh, Sharanabasappa
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摘要

目的:登革热曾被视为一种典型的发热性疾病,但随着登革热扩展综合征(EDS)的出现,它已成为全球关注的焦点。EDS 的特点是影响中枢神经系统、肝脏、心脏和肾脏等多个器官系统的非典型严重表现。这种综合征挑战了人们对登革热的传统认识,需要提高临床认识、及时干预和全面研究。合并感染使临床情况更加复杂,强调了准确诊断和针对性治疗策略的必要性。研究方法这项前瞻性观察研究于 2018 年 1 月至 2021 年 1 月在海得拉巴 Malakpet 的 Yashoda 超级专科医院进行。研究旨在识别和分析各年龄段登革热患者的非典型表现。纳入标准包括实验室确诊的登革热病例,其非典型表现显示为 EDS。数据收集包括全面的临床、实验室和放射学信息。采用 SPSS 软件进行伦理考虑和统计分析。结果研究分析了150例EDS病例,包括脑病、心肌炎、急性肝功能衰竭和肾功能损害等非典型表现。中枢神经系统受累是最常见的非典型表现(20%),其次是心肌炎(15%)和急性肝功能衰竭(10%)。5%的病例出现肾功能损害。25%的EDS病例合并感染,使临床治疗更加复杂。EDS患者的死亡率为5%,这强调了早期识别和积极干预特定器官的重要性。结论登革热扩展综合征挑战了人们对登革热的传统认识,突出了非典型表现和合并感染。提高临床意识、广泛鉴别诊断和积极的管理策略对于解决 EDS 的多面性至关重要。需要进一步开展研究,为这种复杂且不断演变的疾病制定有针对性的干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
EXPANDED DENGUE SYNDROME AND ATYPICAL MANIFESTATIONS
Objective: Dengue fever, once seen as a classical febrile illness, has transformed into a global concern with the emergence of Expanded Dengue Syndrome (EDS). EDS is characterized by atypical and severe manifestations affecting multiple organ systems, including the central nervous system, liver, heart, and kidneys. This syndrome challenges the traditional understanding of dengue and necessitates heightened clinical awareness, timely intervention, and comprehensive research. Co-infections further complicate the clinical landscape, emphasizing the need for accurate diagnosis and targeted therapeutic strategies. Methods: This prospective observational study was conducted at Yashoda Super Specialty Hospital, Malakpet, Hyderabad, from January 2018 to January 2021. The study aimed to identify and analyze atypical presentations of dengue fever in patients of all age groups. Inclusion criteria involved laboratory-confirmed dengue cases with atypical manifestations indicative of EDS. Data collection included comprehensive clinical, laboratory, and radiological information. Ethical considerations and statistical analysis were conducted using SPSS software. Results: The study analyzed 150 cases of EDS, encompassing atypical manifestations such as encephalopathy, myocarditis, acute liver failure, and renal impairment. CNS involvement was the most common atypical manifestation (20%), followed by myocarditis (15%) and acute liver failure (10%). Renal impairment was observed in 5% of cases. Co-infections were identified in 25% of EDS cases, further complicating clinical management. The mortality rate among EDS patients was 5%, emphasizing the importance of early recognition and aggressive organ-specific interventions. Conclusion: Expanded Dengue Syndrome challenges the conventional perception of dengue fever, highlighting atypical manifestations and co-infections. Heightened clinical awareness, a broad differential diagnosis, and aggressive management strategies are essential for addressing the multifaceted nature of EDS. Further research is needed to develop targeted interventions for this complex and evolving disease.
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