一些草本抗抑郁植物概述

TANMAYI PATIL, MOHAN KALE, RUTUJA KUMBHAR, VISHAL BODKE, KOMAL CHAUDHARI
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引用次数: 0

摘要

抑郁症是一种多种多样的情绪病,其分类和治疗方法有很多。这种疾病是由 5-羟色胺、NA 和 MAO-A 抑制和刺激等因素引起的。症状包括对快乐的好奇心降低、不适当的负罪感或无价值感、饥饿感和性欲下降、失眠和持续的自杀念头。有几种合成药物可用于治疗抑郁症,但并非所有药物都能让患者感到快乐,其中一些还可能有负面副作用。许多人转而采用广受欢迎的传统草药疗法,以避免对抗疗法的负面影响。由于中草药应用广泛、疗效显著、不良反应极小甚至可以忽略不计,目前已在全球范围内广泛使用。一些药用植物和从这些植物中提取的药物通过其药用成分的综合作用显示出抗抑郁特性。我们将在这篇综述中讨论有望用于治疗重度抑郁症的新型药物产品。我们探讨了选择性靶向受体(包括阿片类受体、G 蛋白偶联受体和代谢谷氨酸受体)的潜在抗抑郁功效。由于它们也可能具有治疗价值,我们还讨论了针对生物过程的物质,包括炎症、肠道微生物群、胆固醇生物合成途径和下丘脑-垂体-肾上腺轴。最后,我们将以图表形式提供所有植物的概要,并概述目前可广泛获取的抗抑郁植物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
AN OVERVIEW OF SOME HERBAL ANTIDEPRESSANT PLANTS
There are numerous ways to categorize and treat depression, which is a diverse mood disease. The illness is caused by factors such as 5-HT, NA, and MAO-A inhibition and stimulation. Reduced curiosity about pleasure, feelings of inappropriate guilt or worthlessness, a drop in hunger and sexual desire, sleeplessness, and persistent suicidal thoughts are some of the symptoms. There are several synthetic medications used to treat depression, but not all of them make patients happy, and some of them may have negative side effects. Many have turned to well-liked traditional herbal remedies to avoid the negative effects of allopathic therapy. Due to their broad application, therapeutic efficacy, and little to negligible adverse effects, herbal medications are currently used worldwide. Several medicinal plants and medicines derived from these plants have shown antidepressant properties by the combined effect of their medicinal constituents. We discuss promising novel medicinal products targets for the management of major depressive illness in this review. We address the potential antidepressant benefits of selectively targeting receptors, including opioid, G-protein-coupled, and metabotropic glutamate receptors. Since they may also have therapeutic value, we also talk about substances that target biological processes, including inflammation, the gut microbiota, the cholesterol biosynthesis pathway, and the hypothalamic-pituitary-adrenal axis. Lastly, we offer a synopsis of all the plants displayed in graphical format, together with an overview of the antidepressant plants which currently are widely accessible.
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