EFFECTIVENESS OF IVERMECTIN AGAINST ECTO- AND ENDO-PARASITIC INVASION OF DOGS

For ecto- and endoparasitic infestations of animals, preparations based on ivermectin are used. That is why the purpose of the work was to conduct a field study to evaluate the effectiveness of the researched drug "Profiverm 1%" (solution for injections) in comparison with the drug "Brovermectin" (solution for injections) against ecto- and endoparasitic infestations of dogs of various breeds, age and gender. According to the results of the acarological examination of the dogs of the experimental and control groups, it was established that they were parasitized by the ear mite Otodectos cynotis with an intensity of 9 to 24 specimens on the surface of the animal's auricle, with an average intensity of infestation of 16.4 ± 1.24 mites per animal. Clinical signs of infection were manifested by itching, the presence of atypical contents in the ears, otodectous foci in the form of scabs and crusts. After subcutaneous injection of the studied drug "Profiverm 1 %" for 7 days, its effectiveness for otodectosis in dogs was 69.7 %, and after the use of the comparison drug "Brovermectin" – 67.6 %. On the 14th day after treatment of dogs with the studied drug "Profiverm 1%", its effectiveness was 95.0 %, and the effectiveness of the comparative drug "Brovermectin" was 93.7 %. On the 21st day of the experiment, both drugs showed 100 % effectiveness in otodectic infestation of dogs. According to the results of helminthological studies, the animals of the experimental and control groups were found to be spontaneously infected with endoparasites, the causative agents of nematodes: Toxocara canis with an intensity of invasion (II) from 98 to 156 eggs in one gram of faeces (ЕGF), Toxascaris leonina – from 68 to 118 ЕGF and Ancylostoma caninum – from 36 to 78 ЕGF. Clinically, nematodes in dogs were manifested by a depressed state, deterioration of appetite, mild diarrhea and vomiting were observed in some animals, paleness of the mucous membranes was noted. The obtained results show that for spontaneous toxocariasis infestation in dogs on the 7th day after deworming, the effectiveness of the studied drug "Profiverm 1%" was 92.5 %, and the comparison drug "Brovermectin" was 90.0 %. On the 14th day after deworming the animals, the effectiveness of both drugs was 100 %. In case of spontaneous toxascarosis infestation of dogs, it was established that on the 7th day after deworming, the effectiveness of the studied drug was 94.1 %, and the effectiveness of the comparison drug was 92.4 %. On the 14th day after deworming the animals, the effectiveness of both drugs was 100 %. Helminthological studies established that the effectiveness of veterinary drugs was 100% for spontaneous аncylostomosеs infestation in dogs 7 and 14 days after the use of the researched drug and the comparator drug in the recommended doses. Field tests showed that the veterinary drug "Profiverm 1 %" and "Brovermectin" with single subcutaneous use in the recommended doses of the manufacturer were well tolerated by animals regardless of age, body weight and breed and did not have a toxic effect on the animal's body.