{"title":"离子介导的热响应性纤维素纳米纤维/聚(N-异丙基丙烯酰胺)混合水凝胶的可调谐溶胀动力学","authors":"Bennie Motloung, Rueben Pfukwa, Bert Klumperman","doi":"10.1002/mame.202300457","DOIUrl":null,"url":null,"abstract":"<p>The tunability of the lower critical solution temperature (LCST) of poly(<i>N</i>-isopropylacrylamide) (PNIPAM) to lower or higher temperatures, as well as the ease of modulation of the LCST phase transition kinetics broadens the scope of application of PNIPAM-based materials in biomedical fields. This work reports a facile approach to formulate a smart, injectable cellulose nanofibril (CNF)/PNIPAM hybrid gel. Hofmeister salts are used to induce ion-mediated gelation of the nanofibrils and PNIPAM chains, resulting in an interpenetrating network (IPN) structure. From rheological measurements, the hybrid material displays excellent structural integrity at room temperature and tunable thermo-stiffening around body temperature. De-swelling kinetics can be modulated by varying the nature and concentration of the Hofmeister ion used. The successful realization of the IPN hybrid gel structure is dependent on the molecular weight of PNIPAM used. Moreover, the hybrid gels show good thermo-reversibility during thermal cycling, as well as excellent injectability and remarkable self-healing post-injection, owing to shear-thinning and thixotropic characters. Since rheology is a crucial technique in the analysis of soft matter and flow behavior is fundamental for the design and synthesis of application-specific viscoelastic materials, the work reported herein provides a rheological basis for careful design and synthesis of smart gels.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"309 8","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202300457","citationCount":"0","resultStr":"{\"title\":\"Ion-Mediated Gelation of Thermo-Responsive Cellulose Nanofibril/Poly(N-isopropylacrylamide) Hybrid Hydrogels with Tunable De-Swelling Kinetics\",\"authors\":\"Bennie Motloung, Rueben Pfukwa, Bert Klumperman\",\"doi\":\"10.1002/mame.202300457\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The tunability of the lower critical solution temperature (LCST) of poly(<i>N</i>-isopropylacrylamide) (PNIPAM) to lower or higher temperatures, as well as the ease of modulation of the LCST phase transition kinetics broadens the scope of application of PNIPAM-based materials in biomedical fields. This work reports a facile approach to formulate a smart, injectable cellulose nanofibril (CNF)/PNIPAM hybrid gel. Hofmeister salts are used to induce ion-mediated gelation of the nanofibrils and PNIPAM chains, resulting in an interpenetrating network (IPN) structure. From rheological measurements, the hybrid material displays excellent structural integrity at room temperature and tunable thermo-stiffening around body temperature. De-swelling kinetics can be modulated by varying the nature and concentration of the Hofmeister ion used. The successful realization of the IPN hybrid gel structure is dependent on the molecular weight of PNIPAM used. Moreover, the hybrid gels show good thermo-reversibility during thermal cycling, as well as excellent injectability and remarkable self-healing post-injection, owing to shear-thinning and thixotropic characters. Since rheology is a crucial technique in the analysis of soft matter and flow behavior is fundamental for the design and synthesis of application-specific viscoelastic materials, the work reported herein provides a rheological basis for careful design and synthesis of smart gels.</p>\",\"PeriodicalId\":18151,\"journal\":{\"name\":\"Macromolecular Materials and Engineering\",\"volume\":\"309 8\",\"pages\":\"\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-05-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202300457\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Macromolecular Materials and Engineering\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/mame.202300457\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromolecular Materials and Engineering","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mame.202300457","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Ion-Mediated Gelation of Thermo-Responsive Cellulose Nanofibril/Poly(N-isopropylacrylamide) Hybrid Hydrogels with Tunable De-Swelling Kinetics
The tunability of the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide) (PNIPAM) to lower or higher temperatures, as well as the ease of modulation of the LCST phase transition kinetics broadens the scope of application of PNIPAM-based materials in biomedical fields. This work reports a facile approach to formulate a smart, injectable cellulose nanofibril (CNF)/PNIPAM hybrid gel. Hofmeister salts are used to induce ion-mediated gelation of the nanofibrils and PNIPAM chains, resulting in an interpenetrating network (IPN) structure. From rheological measurements, the hybrid material displays excellent structural integrity at room temperature and tunable thermo-stiffening around body temperature. De-swelling kinetics can be modulated by varying the nature and concentration of the Hofmeister ion used. The successful realization of the IPN hybrid gel structure is dependent on the molecular weight of PNIPAM used. Moreover, the hybrid gels show good thermo-reversibility during thermal cycling, as well as excellent injectability and remarkable self-healing post-injection, owing to shear-thinning and thixotropic characters. Since rheology is a crucial technique in the analysis of soft matter and flow behavior is fundamental for the design and synthesis of application-specific viscoelastic materials, the work reported herein provides a rheological basis for careful design and synthesis of smart gels.
期刊介绍:
Macromolecular Materials and Engineering is the high-quality polymer science journal dedicated to the design, modification, characterization, processing and application of advanced polymeric materials, including membranes, sensors, sustainability, composites, fibers, foams, 3D printing, actuators as well as energy and electronic applications.
Macromolecular Materials and Engineering is among the top journals publishing original research in polymer science.
The journal presents strictly peer-reviewed Research Articles, Reviews, Perspectives and Comments.
ISSN: 1438-7492 (print). 1439-2054 (online).
Readership:Polymer scientists, chemists, physicists, materials scientists, engineers
Abstracting and Indexing Information:
CAS: Chemical Abstracts Service (ACS)
CCR Database (Clarivate Analytics)
Chemical Abstracts Service/SciFinder (ACS)
Chemistry Server Reaction Center (Clarivate Analytics)
ChemWeb (ChemIndustry.com)
Chimica Database (Elsevier)
COMPENDEX (Elsevier)
Current Contents: Physical, Chemical & Earth Sciences (Clarivate Analytics)
Directory of Open Access Journals (DOAJ)
INSPEC (IET)
Journal Citation Reports/Science Edition (Clarivate Analytics)
Materials Science & Engineering Database (ProQuest)
PASCAL Database (INIST/CNRS)
Polymer Library (iSmithers RAPRA)
Reaction Citation Index (Clarivate Analytics)
Science Citation Index (Clarivate Analytics)
Science Citation Index Expanded (Clarivate Analytics)
SciTech Premium Collection (ProQuest)
SCOPUS (Elsevier)
Technology Collection (ProQuest)
Web of Science (Clarivate Analytics)