非酒精性脂肪肝与结肠息肉的关系:台湾病例对照研究

IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Kuan-Fu Liao, Pei-Ying Chung, Yu-Hung Kuo, Shih-Wei Lai
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引用次数: 0

摘要

研究目的研究台湾非酒精性脂肪肝(NAFLD)与结肠息肉之间的潜在关联。方法。我们利用台湾国民健康保险计划 2006-2015 年的理赔数据作为数据来源。我们进行了一项病例对照研究,研究对象为 20 岁及以上患有和未患有结肠息肉的人群。病例包括通过诊断代码确诊的结肠息肉患者。对照组选自无结肠息肉者,根据性别、年龄和合并症与病例匹配。非酒精性脂肪肝是根据诊断代码确定的。采用带有几率比(OR)和 95% 置信区间(CI)的逻辑回归模型来评估非酒精性脂肪肝与结肠息肉之间的关系。研究结果研究共纳入 16,890 例结肠息肉患者和 67,560 例无结肠息肉的匹配对照。研究对象的平均年龄为 57 岁,约 61% 为男性。在患有结肠息肉的病例中,1.0%确诊为非酒精性脂肪肝,而对照组中只有 0.4% 表现为非酒精性脂肪肝。在对混杂变量进行调整后,多变量逻辑回归模型显示,非酒精性脂肪肝与结肠息肉之间存在显著的统计学关联,几率比为 2.32(95% CI = 1.91-2.82)。结论这项病例对照研究表明,非酒精性脂肪肝与结肠息肉之间存在正相关。这些结果有助于我们了解非酒精性脂肪肝与胃肠道健康之间的潜在联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association between Nonalcoholic Fatty Liver Disease and Colon Polyps: A Case-Control Study in Taiwan

Association between Nonalcoholic Fatty Liver Disease and Colon Polyps: A Case-Control Study in Taiwan

Objective. To investigate the potential association between nonalcoholic fatty liver disease (NAFLD) and colon polyps in Taiwan. Methods. We utilized 2006–2015 claims data of the Taiwan National Health Insurance Program as a data source. A case-control study was conducted, involving individuals 20 years or older with and without colon polyps. Cases comprised individuals diagnosed with colon polyps, identified through diagnosis codes. Controls were selected from individuals without colon polyps, matched to cases based on sex, age, and comorbidities. NAFLD was identified based on diagnosis codes. The logistic regression model with odds ratio (OR) and 95% confidence interval (CI) was employed to assess the association between NAFLD and colon polyps. Results. The study included 16,890 cases with colon polyps and 67,560 matched controls without colon polyps. The mean age was 57 years old and about 61% of study subjects were males. Among cases with colon polyps, 1.0% had a diagnosis of NAFLD, whereas only 0.4% exhibited NAFLD in the control group. After adjustment for confounding variables, a multivariable logistic regression model revealed a statistically significant association between NAFLD and colon polyps, with an odds ratio of 2.32 (95% CI = 1.91–2.82). Conclusion. This case-control study suggests a positive association between NAFLD and colon polyps. These results contribute to our understanding of the potential links between NAFLD and gastrointestinal health.

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来源期刊
CiteScore
5.30
自引率
0.00%
发文量
274
审稿时长
3-8 weeks
期刊介绍: IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.
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