细胞为什么需要铁:铁利用简编》。

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Megan R Teh, Andrew E Armitage, Hal Drakesmith
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引用次数: 0

摘要

缺铁症在全球普遍存在,会导致一系列发育、血液学、免疫学、神经学和心脏代谢方面的损伤,并伴有从慢性疲劳到脱发等各种症状。在细胞内,数百种不同的蛋白质以各种方式利用铁。在这里,我们回顾了受铁调节的分子活动与缺铁的病理生理效应之间的联系。我们确定了特别依赖铁的特定酶组、生化途径、细胞功能和细胞系。我们举例说明了缺铁如何影响多个关键系统和组织,包括免疫、激素合成和胆固醇代谢。我们认为,从机理上进一步了解细胞铁如何影响生理过程,可能会为各种疾病带来新的治疗机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Why cells need iron: a compendium of iron utilisation.

Iron deficiency is globally prevalent, causing an array of developmental, haematological, immunological, neurological, and cardiometabolic impairments, and is associated with symptoms ranging from chronic fatigue to hair loss. Within cells, iron is utilised in a variety of ways by hundreds of different proteins. Here, we review links between molecular activities regulated by iron and the pathophysiological effects of iron deficiency. We identify specific enzyme groups, biochemical pathways, cellular functions, and cell lineages that are particularly iron dependent. We provide examples of how iron deprivation influences multiple key systems and tissues, including immunity, hormone synthesis, and cholesterol metabolism. We propose that greater mechanistic understanding of how cellular iron influences physiological processes may lead to new therapeutic opportunities across a range of diseases.

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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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