Gasdermin D棕榈酰化：裂解还是不裂解？

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-06-01 Epub Date: 2024-05-16 DOI:10.1016/j.it.2024.05.001

Laurel Stine, Fiachra Humphries

引用次数: 0

摘要

最近的研究发现，gasdermin D (GSDMD)中的 Cys191 是一个高度靶向的调控模块，控制着火化过程。最近，Du、Healy 等人利用化学生物学和遗传模型确定了 GSDMD 棕榈酰化是 GSDMD 激活的关键调控步骤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gasdermin D palmitoylation: to cleave or not to cleave?

Recent studies have identified Cys¹⁹¹ in gasdermin D (GSDMD) as a highly targeted regulatory module controlling pyroptosis. Using chemical biology and genetic models, Du, Healy et al. recently identified GSDMD palmitoylation as a key regulatory step in GSDMD activation.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.