急性疼痛治疗中的新兴药物和策略:新型钠和钙通道阻滞剂、多肽类药物以及非药物方法不断演变的作用。

IF 3.2 2区 医学 Q2 CLINICAL NEUROLOGY
Current Pain and Headache Reports Pub Date : 2024-09-01 Epub Date: 2024-05-18 DOI:10.1007/s11916-024-01265-z
Alan D Kaye, Driskell R Greene, Catherine Nguyen, Amanda Ragland, Mason P Granger, William Peyton Wilhite, Kylie Dufrene, Sahar Shekoohi, Christopher L Robinson
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引用次数: 0

摘要

审查目的:本调查评估了新型药物治疗技术的整合情况,以加强治疗选择,同时改善急性疼痛治疗中的患者预后。在这方面,我们重点确定了开发和利用靶向给药系统等尖端制药技术以及非药物干预措施在解决急性疼痛状态中的作用。由于需要提高患者舒适度和减少不良反应,因此有必要在这一领域开展进一步研究:本研究讨论了最近的创新和技术,包括针对钠和钙通道的药理药物、基于肽的药理药物以及舒缓音乐或虚拟现实等非药理镇痛方法。本次调查包括对当前有关这些创新技术应用的文献进行回顾,分析其作用机制、药代动力学和临床效果。我们的研究还调查了在缓解疼痛、减少副作用和提高患者依从性方面的潜在益处。考虑到成本、可及性和监管方面的因素,研究批判性地探讨了在急性疼痛管理中实施这些技术的相关挑战和注意事项。此外,研究还重点介绍了案例研究和临床试验,这些案例研究和临床试验证明了这些新型药物治疗技术在现实世界中的实际意义。研究结果旨在让医护人员全面了解急性疼痛治疗领域不断变化的情况,同时指导未来的研究和临床实践,以优化这些技术的使用,加强对患者的护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emerging Medications and Strategies in Acute Pain Management: Evolving Role of Novel Sodium and Calcium Channel Blockers, Peptide-Based Pharmacologic Drugs, and Non-Medicinal Methods.

Purpose of review: The present investigation evaluated integration of novel medication technology to enhance treatment options, while improving patient outcomes in acute pain management. In this regard, we focused on determining the role of development and utilization of cutting-edge pharmaceutical advancements, such as targeted drug delivery systems, as well as non-pharmacologic interventions in addressing acute pain states. Further research in this area is warranted related to the need for increased patient comfort and reduced adverse effects.

Recent findings: Recent innovations and techniques are discussed including pharmacologic drugs targeting sodium and calcium channels, peptide-based pharmacologic drugs, and non-medicinal methods of alleviating pain such as soothing music or virtual reality. The present investigation included review of current literature on the application of these innovative technologies, analyzing mechanisms of action, pharmacokinetics, and clinical effectiveness. Our study also investigated the potential benefits in terms of pain relief, reduced side effects, and improved patient adherence. The research critically examines the challenges and considerations associated with implementing these technologies in acute pain management, considering factors like cost, accessibility, and regulatory aspects. Additionally, case studies and clinical trials are highlighted which demonstrate practical implications of these novel medication technologies in real-world scenarios. The findings aim to provide healthcare professionals with a comprehensive understanding of the evolving landscape in acute pain management while guiding future research and clinical practices toward optimizing their use in enhancing patient care.

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来源期刊
Current Pain and Headache Reports
Current Pain and Headache Reports CLINICAL NEUROLOGY-
CiteScore
6.10
自引率
2.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings regarding the diagnosis, treatment, and management of pain and headache. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of pain and headache. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anesthetic techniques in pain management, cluster headache, neuropathic pain, and migraine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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