将纹状体多巴胺能不对称与人格特质联系起来:赌博障碍的启示

IF 2.4 3区 心理学 Q2 PSYCHOLOGY, MULTIDISCIPLINARY
Journal of Gambling Studies Pub Date : 2024-12-01 Epub Date: 2024-05-16 DOI:10.1007/s10899-024-10311-9
Francesco Di Carlo, Mauro Pettorruso, Mario Santorelli, Fabrizio Cocciolillo, Giacomo d'Andrea, Marco Di Nicola, Stefano S Sensi, Giovanni Martinotti, Jon E Grant, Giovanni Camardese, Daniela Di Giuda
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引用次数: 0

摘要

多巴胺在赌博障碍(GD)的病理生理学中的作用仍未被完全理解,有关突触前和突触后结构以及多巴胺能合成的研究结果各不相同。本研究旨在探讨123I-FP-CIT SPECT评估的GD受试者纹状体多巴胺转运体(DAT)侧化和不对称指数与克隆宁格气质和性格量表(TCI)测量的气质特征之间的潜在相关性。研究发现,尾状体和普坦门的DAT结合不对称与避免伤害和寻求新奇的气质维度之间存在显著关联。具体来说,寻求新奇的高分与左侧尾状核相对于右侧的DAT结合力增加有关,而伤害回避的高分则与右侧普塔门相对于左侧的DAT结合力增加有关。这些观察结果可能意味着,基底神经节中DAT表达的不对称性可能是情绪处理和行为指导中半球不对称性的结果。总之,我们的研究提供了支持DAT不对称性、气质维度和广东话之间关系的证据。今后的研究可以针对突触后受体进行检查,以便更全面地了解多巴胺在基底节回路中对赌博障碍的影响。如果在更大的队列中得到证实,这些发现可能会对治疗行为成瘾的个性化神经调节疗法产生重大影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Linking Striatal Dopaminergic Asymmetry with Personality Traits: Insights from Gambling Disorder.

Linking Striatal Dopaminergic Asymmetry with Personality Traits: Insights from Gambling Disorder.

The role of dopamine in the pathophysiology of gambling disorder (GD) remains incompletely understood, with disparate research findings concerning presynaptic and postsynaptic structures and dopaminergic synthesis. The aim of this study was to investigate potential correlations between striatal dopamine transporter (DAT) lateralization and asymmetry index, as assessed by 123I-FP-CIT SPECT, and temperamental traits, as measured by Cloninger's Temperament and Character Inventory (TCI), in GD subjects. Significant associations were found between DAT binding asymmetries in the caudate and putamen and the temperamental dimensions of harm avoidance and novelty seeking. Specifically, high novelty seeking scores correlated with increased DAT binding in the left caudate relative to the right, whereas higher harm avoidance scores corresponded to increased DAT binding in the right putamen relative to the left. These observations potentially imply that the asymmetry in DAT expression in the basal ganglia could be an outcome of hemispheric asymmetry in emotional processing and behavioural guidance. In summary, our study provides evidence supporting the relationship between DAT asymmetries, temperamental dimensions and GD. Future investigations could be directed towards examining postsynaptic receptors to gain a more comprehensive understanding of dopamine's influence within the basal ganglia circuit in disordered gambling. If confirmed in larger cohorts, these findings could have substantial implications for the tailoring of individualized neuromodulation therapies in the treatment of behavioural addictions.

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来源期刊
CiteScore
5.00
自引率
16.70%
发文量
72
期刊介绍: Journal of Gambling Studies is an interdisciplinary forum for the dissemination on the many aspects of gambling behavior, both controlled and pathological, as well as variety of problems attendant to, or resultant from, gambling behavior including alcoholism, suicide, crime, and a number of other mental health problems. Articles published in this journal are representative of a cross-section of disciplines including psychiatry, psychology, sociology, political science, criminology, and social work.
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