基于正念的干预对早产青少年神经行为功能的影响及其与大规模大脑网络的关联。

IF 5 3区 医学 Q1 CLINICAL NEUROLOGY
Psychiatry and Clinical Neurosciences Pub Date : 2024-07-01 Epub Date: 2024-05-17 DOI:10.1111/pcn.13675
Vanessa Siffredi, Maria Chiara Liverani, Natalia Fernandez, Lorena G A Freitas, Cristina Borradori Tolsa, Dimitri Van De Ville, Petra Susan Hüppi, Russia Ha-Vinh Leuchter
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引用次数: 0

摘要

目的:早产青少年(VPT;方法:对 32 名早产青少年进行 MBI 之前和之后的神经行为评估和静息态功能磁共振成像:对 32 名 VPT 青少年在 MBI 前后进行了神经行为评估和静息态功能磁共振成像。将 VPT 参与者的神经行为能力与足月对照组进行比较。在 VPT 组中,使用创新驱动共激活模式框架提取了动态功能连接。可靠变化指数用于量化 MBI 后的变化。采用多变量数据驱动法探讨了MBI相关神经行为测量变化与时空大脑动态之间的关联:结果:与足月出生的对照组相比,VPT青少年在MBI前表现出执行功能和社会情感功能下降。MBI后,VPT组之前降低的所有测量指标均有明显改善。只有执行功能的提高与大规模大脑网络(包括前边缘、杏仁核-海马体、背外侧前额叶和视觉网络)激活持续时间的可靠变化有关:结论:MBI后执行功能的改善与休息时大规模大脑网络动态的可靠变化有关。这些变化包括前边缘、杏仁核-海马、背外侧前额叶和视觉网络,它们与不同的执行过程有关,包括自我调节、注意控制和对相关感觉刺激的注意意识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of a mindfulness-based intervention on neurobehavioral functioning and its association with large-scale brain networks in preterm young adolescents.

Aim: Adolescents born very preterm (VPT; <32 weeks of gestation) face an elevated risk of executive, behavioral, and socioemotional difficulties. Evidence suggests beneficial effects of mindfulness-based intervention (MBI) on these abilities. This study seeks to investigate the association between the effects of MBI on executive, behavioral, and socioemotional functioning and reliable changes in large-scale brain networks dynamics during rest in VPT young adolescents who completed an 8-week MBI program.

Methods: Neurobehavioral assessments and resting-state functional magnetic resonance imaging were performed before and after MBI in 32 VPT young adolescents. Neurobehavioral abilities in VPT participants were compared with full-term controls. In the VPT group, dynamic functional connectivity was extracted by using the innovation-driven coactivation patterns framework. The reliable change index was used to quantify change after MBI. A multivariate data-driven approach was used to explore associations between MBI-related changes on neurobehavioral measures and temporal brain dynamics.

Results: Compared with term-born controls, VPT adolescents showed reduced executive and socioemotional functioning before MBI. After MBI, a significant improvement was observed for all measures that were previously reduced in the VPT group. The increase in executive functioning, only, was associated with reliable changes in the duration of activation of large-scale brain networks, including frontolimbic, amygdala-hippocampus, dorsolateral prefrontal, and visual networks.

Conclusion: The improvement in executive functioning after an MBI was associated with reliable changes in large-scale brain network dynamics during rest. These changes encompassed frontolimbic, amygdala-hippocampus, dorsolateral prefrontal, and visual networks that are related to different executive processes including self-regulation, attentional control, and attentional awareness of relevant sensory stimuli.

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来源期刊
CiteScore
7.40
自引率
4.20%
发文量
181
审稿时长
6-12 weeks
期刊介绍: PCN (Psychiatry and Clinical Neurosciences) Publication Frequency: Published 12 online issues a year by JSPN Content Categories: Review Articles Regular Articles Letters to the Editor Peer Review Process: All manuscripts undergo peer review by anonymous reviewers, an Editorial Board Member, and the Editor Publication Criteria: Manuscripts are accepted based on quality, originality, and significance to the readership Authors must confirm that the manuscript has not been published or submitted elsewhere and has been approved by each author
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