大戟科植物 helioscopia 中两种新的麻风烷二萜类化合物对自噬通量具有活性。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-15 DOI:10.1080/10286020.2024.2345181

Ming-You Peng , Xiong Zhang , Qin-Dan Li , En-Ming Feng , Lu Chen , Hu-Cheng Yang , Bing Guo , Ying-Tong Di , Lei Tang , Rong-Can Luo , Ying Yan

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引用次数: 0

摘要

研究人员从大戟科植物泽泻的全草中分离出九种麻风烷二萜类化合物，其中包括两种新化合物--泽泻素 A（1）和泽泻素 B（2）。综合光谱数据分析和 ECD 计算阐明了它们的结构，包括绝对构型。使用 HM mCherry-GFP-LC3 细胞，通过流式细胞仪评估了所有化合物对自噬通量的生物活性。化合物 1、3、4、5、8 和 9 显著提高了自噬通量。

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Two new jatrophane diterpenoids from Euphorbia helioscopia with activity towards autophagic flux

Nine jatrophane diterpenoids were isolated from the whole plant Euphorbia helioscopia, including two new ones, helioscopnins A (1) and B (2). Comprehensive spectroscopic data analysis and ECD calculations elucidated their structures, including absolute configurations. All compounds were evaluated for bioactivity towards autophagic flux by flow cytometry using HM mCherry-GFP-LC3 cells. Compounds 1, 3, 4, 5, 8, and 9 significantly increased autophagic flux.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.