盐生曲霉 GXIMD00544 中的一对阿托异构体 Secofumitremorgins C 和 D。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-15 DOI:10.1080/10286020.2024.2349664

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引用次数: 0

摘要

从盐生真菌 Aspergillus fumigatus GXIMD00544 中分离出一对阿托异构体 secofumitremorgins C (1a) 和 D (1b)，以及 15 种已知生物碱 (2-16)。通过详细的光谱数据、化学反应和量子化学计算，阐明了阿托异构体 1a 和 1b 的结构。化合物 1 和 8 对甘蔗镰刀菌相关的植物病原真菌孢子萌发具有抗真菌作用，在 100 µM 浓度下的抑制率分别为 53% 和 77%。异构体 1 还对 Balanus amphitrite 幼虫沉降具有防污潜力，在 100 µM 浓度下的抑制率为 96%。

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Secofumitremorgins C and D, a pair of atropisomers from saltern-derived fungus Aspergillus fumigatus GXIMD00544

A pair of atropisomers secofumitremorgins C (1a) and D (1b), together with fifteen known alkaloids (2-16), were isolated from a saltern-derived fungus Aspergillus fumigatus GXIMD00544. The structures of atropisomers 1a and 1b were elucidated by the detailed spectroscopic data, chemical reaction and quantum chemical calculations. Compounds 1 and 8 displayed antifungal spore germination effects against plant pathogenic fungus associated with sugarcane Fusarium sp. with inhibitory rates of 53% and 77% at the concentration of 100 µM, repectively. Atropisomers 1 also exhibited antifouling potential against Balanus amphitrite larval settlement with an inhibitory rate of 96% at the concentration of 100 µM.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.