来自日光层青霉 NX-05-G-3 的两种新的 HMG 结合型巨噬细胞蛋白 H 和 L。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-16 DOI:10.1080/10286020.2024.2347530

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引用次数: 0

摘要

从灭菌水稻培养基培养的青霉(Penicillium sp. NX-05-G-3)中分离出巨噬细胞素H(4)和L(5)、两种罕见的HMG-结合型巨噬细胞素以及三种已知的巨噬细胞素(1-3)、三种DMOA衍生的美拉特萜类化合物(6-8)和两种麦角甾醇衍生物(9-10)。它们的结构通过一维和二维核磁共振得以阐明。评估了所有化合物的细胞毒性，发现化合物 1 和 2 对人癌细胞株 Hela、SCC15、MDA-MB-453 和 A549 具有广泛的细胞毒性，IC50 值介于 17.6 至 32.8 µM 之间。

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Macrophorins H and L, two new HMG-conjugate macrophorins from rihzospheric Penicillium sp. NX-05-G-3

Macrophorins H (4) and L (5), two rare HMG-conjugate macrophorins along with three known macrophorins (1-3), three DMOA-derived meroterpenoids (6-8) and two ergosterol derivates (9-10) were isolated from sterilized rice medium cultured Penicillium sp. NX-05-G-3. Their structures were elucidated by 1D and 2D NMR. The cytotoxicities of all compounds were evaluated, and compounds 1 and 2 showed extensive cytotoxicity against human cancer cell lines Hela, SCC15, MDA-MB-453 and A549, with IC₅₀ values ranging from 17.6 to 32.8 µM.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.