来自 Cayratia geniculata 的糖苷成分。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-16 DOI:10.1080/10286020.2024.2347521

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引用次数: 0

摘要

通过各种色谱分离，从 Cayratia geniculata 茎和叶的甲醇提取物中分离出了六种苷衍生物（1-6），其中包括一种名为 cayratioside（1）的新ent-labdane 葡萄糖苷。通过对一维、二维核磁共振和 HRESIQTOF 质谱的详细分析，阐明了它们的结构。此外，还评估了 1-6 对 RAW264.7 细胞中 LPS 诱导的 NO 生成的抑制作用。在分离出的化合物中，1 表现出中等活性，IC50 值为 59.65 ± 1.85 µM。

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Glycoside constituents from Cayratia geniculata

Using various chromatographic separations, six glycoside derivatives (1–6), including one new ent-labdane glucoside named cayratioside (1), were isolated from the methanol extract of Cayratia geniculata stems and leaves. Their structures were elucidated by detailed analysis of the 1D, 2D NMR, and HRESIQTOF mass spectra. The inhibitory effect of 1–6 on LPS-induced NO production in RAW264.7 cells was also evaluated. Among isolated compounds, 1 exhibited moderate activity with an IC₅₀ value of 59.65 ± 1.85 µM.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.