补骨脂素对谷氨酸脱羧酶表达和抑制性突触发育的影响

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-15 DOI:10.1080/10286020.2024.2346297

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引用次数: 0

摘要

γ-氨基丁酸（GABA）是兴奋/抑制平衡所需的一种主要抑制性神经递质，由 GABA 能神经元中的谷氨酸脱羧酶（GADs）合成。谷氨酸脱羧酶的水平和活性与 GABA 和神经传递密切相关。GADs 和 GABA 的失调与各种神经系统疾病有关。这项研究利用榛子种子中的补骨脂素来研究它对初级皮层神经元中 GAD 水平和调节机制的影响。补骨脂素通过转录调控降低了 GAD67。这种降低并非由 N-甲基-D-天冬氨酸受体介导。此外，补骨脂素还能抑制原发性海马神经元抑制性突触的形成。

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Effects of psoralidin on the expression of glutamate decarboxylases and inhibitory synapse development

Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter required for excitation/inhibition balance is synthesized by the glutamic acid decarboxylases (GADs) in GABAergic neurons. The levels and activity of GADs are strongly correlated with GABA and neural transmission. Dysregulation of GADs and GABA is associated with various neurological disorders. The study used psoralidin, found in the seeds of Psoralea corylifolia, to investigate its effect on GAD levels and regulatory mechanisms in primary cortical neurons. Psoralidin reduced GAD67 through transcriptional regulation. The reduction was not mediated by the N-methyl-D-aspartate receptor. Additionally, psoralidin attenuated the formation of inhibitory synapses in primary hippocampal neurons.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.