评估纹理和颜色增强成像(TXI)观察对检测结直肠病变的疗效的前瞻性多中心随机对照试验(deTXIon 研究)方案。

IF 1.9 4区 医学 Q3 ONCOLOGY
Yutaka Saito, Naoya Toyoshima, Yasuhiko Mizuguchi, Taku Sakamoto, Toshio Uraoka, Hiroaki Ikematsu, Naoto Tamai, Takahisa Matsuda, Masashi Misawa, Kinichi Hotta, Taro Shibata
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引用次数: 0

摘要

结肠镜检查是检测和切除腺瘤或早期癌症以降低结肠直肠癌发病率和死亡率的黄金标准。最近的一项观察性研究显示,纹理和颜色增强成像(TXI)可提高结肠镜检查中息肉的检出率。这项随机对照试验有六家日本医疗机构参与,旨在证实在结肠镜检查期间,纹理和颜色增强成像(TXI)在检测结肠直肠病变方面优于标准白光成像(WLI)。在为期一年的研究期间,将有 960 名患者参加试验,其中 TXI 组和 WLI 组各有 480 名患者。主要终点是每次手术检测到腺瘤的平均数量。次要终点包括腺瘤检出率、晚期腺瘤检出率、息肉检出率、扁平息肉检出率、凹陷病变检出率、每次手术检出的平均息肉数、无柄锯齿状病变(SSL)检出率、每次手术检出的平均锯齿状病变数和不良事件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protocol for a prospective multicenter randomized controlled trial to evaluate the efficacy of texture and color enhancement imaging (TXI) observation in the detection of colorectal lesions (deTXIon study).

Colonoscopy is the gold standard for detecting and resecting adenomas or early stage cancers to reduce the incidence and mortality rates of colorectal cancer. In a recent observational study, texture and color enhancement imaging (TXI) was reported to improve polyp detection during colonoscopy. This randomized controlled trial involving six Japanese institutions aims to confirm the superiority of TXI over standard white-light imaging (WLI) in detecting colorectal lesions during colonoscopy. During the 1-year study period, 960 patients will be enrolled, with 480 patients in the TXI and WLI groups. The primary endpoint is the mean number of adenomas detected per procedure. The secondary endpoints include adenoma detection rate, advanced adenoma detection rate, polyp detection rate, flat polyp detection rate, depressed lesion detection rate, mean polyps detected per procedure, sessile serrated lesion (SSL) detection rate, mean SSLs detected per procedure and adverse events.

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来源期刊
CiteScore
3.70
自引率
8.30%
发文量
177
审稿时长
3-8 weeks
期刊介绍: Japanese Journal of Clinical Oncology is a multidisciplinary journal for clinical oncologists which strives to publish high quality manuscripts addressing medical oncology, clinical trials, radiology, surgery, basic research, and palliative care. The journal aims to contribute to the world"s scientific community with special attention to the area of clinical oncology and the Asian region. JJCO publishes various articles types including: ・Original Articles ・Case Reports ・Clinical Trial Notes ・Cancer Genetics Reports ・Epidemiology Notes ・Technical Notes ・Short Communications ・Letters to the Editors ・Solicited Reviews
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