子宫内膜癌和增生中的端粒和端粒酶。

IF 3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Archives of Medical Science Pub Date : 2024-03-30 eCollection Date: 2024-01-01 DOI:10.5114/aoms/186189

Anna Pańczyszyn, Ewa Boniewska-Bernacka, Karolina Włodarczyk, Iwona Wertel, Anna Goc

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引用次数: 0

摘要

简介：该研究旨在测量正常子宫内膜、子宫内膜增生症和癌症的端粒长度（TL）和端粒酶表达：该研究旨在测量正常子宫内膜、子宫内膜增生症和癌症患者的端粒长度（TL）和端粒酶表达：方法：从117名患者的子宫内膜样本中分离出总RNA和DNA。方法：从117例患者的子宫内膜样本中分离出总RNA和DNA，采用RT-PCR方法测定端粒酶的表达和相对端粒长度：结果：与增生组和子宫内膜癌组相比，对照组的端粒最长。只有子宫内膜癌组的端粒酶表达与端粒长度呈正相关：结论：子宫内膜癌的端粒延长是由端粒酶介导的，但端粒长度可能不是子宫内膜癌发展的指标。

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Telomeres and telomerase in endometrial cancer and hyperplasia.

Introduction: The study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer.

Methods: Total RNA and DNA were isolated from endometrium samples of 117 patients. The RT-PCR method was used to determine telomerase expression and relative telomere length.

Results: The control group had the longest telomeres in comparison to the hyperplasia and endometrial cancer groups. Only in the endometrial cancer group was telomerase expressed and positively correlated with telomere length.

Conclusions: Telomere extension in endometrial cancer is mediated by telomerase, but telomere length may not be an indicator of endometrioid cancer development.

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来源期刊

Archives of Medical Science 医学-医学：内科

CiteScore

4.90

自引率

7.90%

发文量

139

审稿时长

1.7 months

期刊介绍： Archives of Medical Science (AMS) publishes high quality original articles and reviews of recognized scientists that deal with all scientific medicine. AMS opens the possibilities for young, capable scientists. The journal would like to give them a chance to have a publication following matter-of-fact, professional review by outstanding, famous medical scientists. Thanks to that they will have an opportunity to present their study results and/or receive useful advice about the mistakes they have made so far. The second equally important aim is a presentation of review manuscripts of recognized scientists about the educational capacity, in order that young scientists, often at the beginning of their scientific carrier, could constantly deepen their medical knowledge and be up-to-date with current guidelines and trends in world-wide medicine. The fact that our educational articles are written by world-famous scientists determines their innovation and the highest quality.