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引用次数: 0
摘要
背景：耳后皮下注射药物作用于内耳的途径尚未完全阐明：比较钆喷酸葡胺（Gd-DTPA）和地塞米松（Dex）在大鼠耳蜗和面神经中的摄取情况：应用磁共振成像技术观察 Gd-DTPA 在面神经和内耳中的分布。我们用不同的方法观察了大鼠注射 Dex 后的摄取情况：静脉注射组（IV）和肌肉注射组（IM）的图像显示，大鼠双侧耳蜗几乎同时显像。而左耳后（PA）注射组则不同步。PA 组（35.406 ± 5.32）的 Gd 在左侧面神经的最大蓄积量（Cmax）大大高于 IV 组（16.765 ± 3.7542）（p 结论：PA 组的 Gd 在左侧面神经的最大蓄积量（Cmax）大大高于 IV 组（p 结论：PA 组的 Gd 在左侧面神经的最大蓄积量（Cmax）大大高于 IV 组（p 结论：PA 组的 Gd 在左侧面神经的最大蓄积量（Cmax）大大高于 IV 组（p与全身给药相比，PA具有Gd和Dex作用时间长、蓄积浓度高的优点，可用于治疗面神经疾病：意义：注射 PA 后，Gd 和 Dex 在大鼠内耳和面神经中的分布可能是独特的。
Uptake of gadolinium and dexamethasone in rat inner ear and facial nerve using different administrations.
Background: The pathway by which drugs are injected subcutaneously behind the ear to act on the inner ear has not been fully elucidated.
Objectives: To compare the uptake of gadopentetate dimeglumine (Gd-DTPA) and dexamethasone (Dex) in the cochlea and facial nerve of rats following different administrations.
Materials and methods: Magnetic resonance imaging was applied to observe the distribution of Gd-DTPA in the facial nerve and inner ear. We observed the uptake of Dex after it was injected with different methods.
Results: Images of the intravenous (IV) and intramuscular (IM) groups showed that the bilateral cochlea of the rat was visualized almost simultaneously. While in the left post-auricular (PA) injection group, it was asynchronous. The maximum accumulation (Cmax) of the Gd in the left facial nerve of the PA group (35.406 ± 5.32) was substantially higher than that of the IV group (16.765 ± 3.7542) (p < .01).
Conclusions: Compared with systemic administration, PA has the advantages of long Gd and Dex action time and high accumulation concentration to treat facial nerve diseases.
Significance: The distribution of Gd and Dex in the inner ear and facial nerve of rats following PA injection might be unique.
期刊介绍：
Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.
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