{"title":"大鼠内耳和面部神经对不同剂量钆和地塞米松的吸收。","authors":"Xing Jin, Yixu Wang, Liyuan Zhang, Hongwei Zheng, Xin Ma, Maoli Duan, Lisheng Yu","doi":"10.1080/00016489.2024.2344807","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The pathway by which drugs are injected subcutaneously behind the ear to act on the inner ear has not been fully elucidated.</p><p><strong>Objectives: </strong>To compare the uptake of gadopentetate dimeglumine (Gd-DTPA) and dexamethasone (Dex) in the cochlea and facial nerve of rats following different administrations.</p><p><strong>Materials and methods: </strong>Magnetic resonance imaging was applied to observe the distribution of Gd-DTPA in the facial nerve and inner ear. We observed the uptake of Dex after it was injected with different methods.</p><p><strong>Results: </strong>Images of the intravenous (IV) and intramuscular (IM) groups showed that the bilateral cochlea of the rat was visualized almost simultaneously. While in the left post-auricular (PA) injection group, it was asynchronous. The maximum accumulation (<i>C</i><sub>max</sub>) of the Gd in the left facial nerve of the PA group (35.406 ± 5.32) was substantially higher than that of the IV group (16.765 ± 3.7542) (<i>p</i> < .01).</p><p><strong>Conclusions: </strong>Compared with systemic administration, PA has the advantages of long Gd and Dex action time and high accumulation concentration to treat facial nerve diseases.</p><p><strong>Significance: </strong>The distribution of Gd and Dex in the inner ear and facial nerve of rats following PA injection might be unique.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Uptake of gadolinium and dexamethasone in rat inner ear and facial nerve using different administrations.\",\"authors\":\"Xing Jin, Yixu Wang, Liyuan Zhang, Hongwei Zheng, Xin Ma, Maoli Duan, Lisheng Yu\",\"doi\":\"10.1080/00016489.2024.2344807\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The pathway by which drugs are injected subcutaneously behind the ear to act on the inner ear has not been fully elucidated.</p><p><strong>Objectives: </strong>To compare the uptake of gadopentetate dimeglumine (Gd-DTPA) and dexamethasone (Dex) in the cochlea and facial nerve of rats following different administrations.</p><p><strong>Materials and methods: </strong>Magnetic resonance imaging was applied to observe the distribution of Gd-DTPA in the facial nerve and inner ear. We observed the uptake of Dex after it was injected with different methods.</p><p><strong>Results: </strong>Images of the intravenous (IV) and intramuscular (IM) groups showed that the bilateral cochlea of the rat was visualized almost simultaneously. While in the left post-auricular (PA) injection group, it was asynchronous. The maximum accumulation (<i>C</i><sub>max</sub>) of the Gd in the left facial nerve of the PA group (35.406 ± 5.32) was substantially higher than that of the IV group (16.765 ± 3.7542) (<i>p</i> < .01).</p><p><strong>Conclusions: </strong>Compared with systemic administration, PA has the advantages of long Gd and Dex action time and high accumulation concentration to treat facial nerve diseases.</p><p><strong>Significance: </strong>The distribution of Gd and Dex in the inner ear and facial nerve of rats following PA injection might be unique.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/00016489.2024.2344807\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/5/16 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00016489.2024.2344807","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/16 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
背景：耳后皮下注射药物作用于内耳的途径尚未完全阐明：比较钆喷酸葡胺（Gd-DTPA）和地塞米松（Dex）在大鼠耳蜗和面神经中的摄取情况：应用磁共振成像技术观察 Gd-DTPA 在面神经和内耳中的分布。我们用不同的方法观察了大鼠注射 Dex 后的摄取情况：静脉注射组（IV）和肌肉注射组（IM）的图像显示，大鼠双侧耳蜗几乎同时显像。而左耳后（PA）注射组则不同步。PA 组（35.406 ± 5.32）的 Gd 在左侧面神经的最大蓄积量（Cmax）大大高于 IV 组（16.765 ± 3.7542）（p 结论：PA 组的 Gd 在左侧面神经的最大蓄积量（Cmax）大大高于 IV 组（p 结论：PA 组的 Gd 在左侧面神经的最大蓄积量（Cmax）大大高于 IV 组（p 结论：PA 组的 Gd 在左侧面神经的最大蓄积量（Cmax）大大高于 IV 组（p与全身给药相比，PA具有Gd和Dex作用时间长、蓄积浓度高的优点，可用于治疗面神经疾病：意义：注射 PA 后，Gd 和 Dex 在大鼠内耳和面神经中的分布可能是独特的。
Uptake of gadolinium and dexamethasone in rat inner ear and facial nerve using different administrations.
Background: The pathway by which drugs are injected subcutaneously behind the ear to act on the inner ear has not been fully elucidated.
Objectives: To compare the uptake of gadopentetate dimeglumine (Gd-DTPA) and dexamethasone (Dex) in the cochlea and facial nerve of rats following different administrations.
Materials and methods: Magnetic resonance imaging was applied to observe the distribution of Gd-DTPA in the facial nerve and inner ear. We observed the uptake of Dex after it was injected with different methods.
Results: Images of the intravenous (IV) and intramuscular (IM) groups showed that the bilateral cochlea of the rat was visualized almost simultaneously. While in the left post-auricular (PA) injection group, it was asynchronous. The maximum accumulation (Cmax) of the Gd in the left facial nerve of the PA group (35.406 ± 5.32) was substantially higher than that of the IV group (16.765 ± 3.7542) (p < .01).
Conclusions: Compared with systemic administration, PA has the advantages of long Gd and Dex action time and high accumulation concentration to treat facial nerve diseases.
Significance: The distribution of Gd and Dex in the inner ear and facial nerve of rats following PA injection might be unique.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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