{"title":"通过锌(II)稳定脒基自由基促进脱氨基方法合成喹唑啉酮支架","authors":"Subarna Manna , Sangita Sahoo , Arnab Rit","doi":"10.1039/d4cc01554a","DOIUrl":null,"url":null,"abstract":"<div><p>Herein, we report a solely ligand centered redox controlled protocol, utilizing a bench stable zinc compound, for the efficient coupling of <em>o</em>-amino amides/esters with nitriles to afford diverse quinazolinone scaffolds and their synthetic utility was showcased <em>via</em> post-modification to access therapeutically relevant compounds. Importantly, mechanistic probes established the reaction pathway that proceeds <em>via</em> aminyl radical.</p></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"60 55","pages":"Pages 7097-7100"},"PeriodicalIF":4.2000,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of quinazolinone scaffolds via a zinc(ii)-stabilized amidyl radical-promoted deaminative approach†\",\"authors\":\"Subarna Manna , Sangita Sahoo , Arnab Rit\",\"doi\":\"10.1039/d4cc01554a\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Herein, we report a solely ligand centered redox controlled protocol, utilizing a bench stable zinc compound, for the efficient coupling of <em>o</em>-amino amides/esters with nitriles to afford diverse quinazolinone scaffolds and their synthetic utility was showcased <em>via</em> post-modification to access therapeutically relevant compounds. Importantly, mechanistic probes established the reaction pathway that proceeds <em>via</em> aminyl radical.</p></div>\",\"PeriodicalId\":67,\"journal\":{\"name\":\"Chemical Communications\",\"volume\":\"60 55\",\"pages\":\"Pages 7097-7100\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1359734524011741\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1359734524011741","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Synthesis of quinazolinone scaffolds via a zinc(ii)-stabilized amidyl radical-promoted deaminative approach†
Herein, we report a solely ligand centered redox controlled protocol, utilizing a bench stable zinc compound, for the efficient coupling of o-amino amides/esters with nitriles to afford diverse quinazolinone scaffolds and their synthetic utility was showcased via post-modification to access therapeutically relevant compounds. Importantly, mechanistic probes established the reaction pathway that proceeds via aminyl radical.
期刊介绍:
ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.