Soheil S. Fakhradini, Mehdi Mosharaf-Dehkordi, Hossein Ahmadikia
{"title":"加强肝癌治疗:探索磁性纳米粒子的频率效应,利用微波进行肿瘤热疗","authors":"Soheil S. Fakhradini, Mehdi Mosharaf-Dehkordi, Hossein Ahmadikia","doi":"10.1016/j.ijthermalsci.2024.109154","DOIUrl":null,"url":null,"abstract":"<div><p>The comprehension of heat transfer mechanisms and their profound implications on biological heat transfer is of paramount importance in the advancement of cancer treatments across all types of malignancies. In the present study, the intricate interplay between Pennes' biothermal principles, Maxwell's electromagnetic equations, and heat generation via a one-slot microwave antenna is resolved numerically. By administering magnetite nanoparticles into malignant tumors, an induced field is engendered, ultimately leading to tumor ablation. By manipulating the microwave frequency, the resultant field is assessed to ascertain the optimal therapeutic modality for this dangerous ailment. The investigation incorporates varying volume percentages of nanoparticles, namely 0.1, 0.05, 0.01, and 0.005 percent, yielding tumor necrosis durations of 2.8, 7.3, 34, and 69 s, respectively. Furthermore, the loss of healthy tissue is quantified as 4.8 %, 15.4 %, 65 %, and 139 %, respectively. Consequently, a direct correlation emerges between the percentage of nanoparticles employed and the diminished treatment duration, as well as reduced adverse effects on healthy tissues, leading to improved patient comfort and minimized thermal-induced injury. Additionally, the influence of frequency within the microwave range (0.3–10 GHz) is probed. Accordingly, when the nanoparticles are injected into the tumor, the frequency has no meaningful difference in the treatment result.</p></div>","PeriodicalId":341,"journal":{"name":"International Journal of Thermal Sciences","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Enhancing liver cancer treatment: Exploring the frequency effects of magnetic nanoparticles for heat-based tumor therapy with microwaves\",\"authors\":\"Soheil S. Fakhradini, Mehdi Mosharaf-Dehkordi, Hossein Ahmadikia\",\"doi\":\"10.1016/j.ijthermalsci.2024.109154\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The comprehension of heat transfer mechanisms and their profound implications on biological heat transfer is of paramount importance in the advancement of cancer treatments across all types of malignancies. In the present study, the intricate interplay between Pennes' biothermal principles, Maxwell's electromagnetic equations, and heat generation via a one-slot microwave antenna is resolved numerically. By administering magnetite nanoparticles into malignant tumors, an induced field is engendered, ultimately leading to tumor ablation. By manipulating the microwave frequency, the resultant field is assessed to ascertain the optimal therapeutic modality for this dangerous ailment. The investigation incorporates varying volume percentages of nanoparticles, namely 0.1, 0.05, 0.01, and 0.005 percent, yielding tumor necrosis durations of 2.8, 7.3, 34, and 69 s, respectively. Furthermore, the loss of healthy tissue is quantified as 4.8 %, 15.4 %, 65 %, and 139 %, respectively. Consequently, a direct correlation emerges between the percentage of nanoparticles employed and the diminished treatment duration, as well as reduced adverse effects on healthy tissues, leading to improved patient comfort and minimized thermal-induced injury. Additionally, the influence of frequency within the microwave range (0.3–10 GHz) is probed. Accordingly, when the nanoparticles are injected into the tumor, the frequency has no meaningful difference in the treatment result.</p></div>\",\"PeriodicalId\":341,\"journal\":{\"name\":\"International Journal of Thermal Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2024-05-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Thermal Sciences\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S129007292400276X\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, MECHANICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Thermal Sciences","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S129007292400276X","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, MECHANICAL","Score":null,"Total":0}
Enhancing liver cancer treatment: Exploring the frequency effects of magnetic nanoparticles for heat-based tumor therapy with microwaves
The comprehension of heat transfer mechanisms and their profound implications on biological heat transfer is of paramount importance in the advancement of cancer treatments across all types of malignancies. In the present study, the intricate interplay between Pennes' biothermal principles, Maxwell's electromagnetic equations, and heat generation via a one-slot microwave antenna is resolved numerically. By administering magnetite nanoparticles into malignant tumors, an induced field is engendered, ultimately leading to tumor ablation. By manipulating the microwave frequency, the resultant field is assessed to ascertain the optimal therapeutic modality for this dangerous ailment. The investigation incorporates varying volume percentages of nanoparticles, namely 0.1, 0.05, 0.01, and 0.005 percent, yielding tumor necrosis durations of 2.8, 7.3, 34, and 69 s, respectively. Furthermore, the loss of healthy tissue is quantified as 4.8 %, 15.4 %, 65 %, and 139 %, respectively. Consequently, a direct correlation emerges between the percentage of nanoparticles employed and the diminished treatment duration, as well as reduced adverse effects on healthy tissues, leading to improved patient comfort and minimized thermal-induced injury. Additionally, the influence of frequency within the microwave range (0.3–10 GHz) is probed. Accordingly, when the nanoparticles are injected into the tumor, the frequency has no meaningful difference in the treatment result.
期刊介绍:
The International Journal of Thermal Sciences is a journal devoted to the publication of fundamental studies on the physics of transfer processes in general, with an emphasis on thermal aspects and also applied research on various processes, energy systems and the environment. Articles are published in English and French, and are subject to peer review.
The fundamental subjects considered within the scope of the journal are:
* Heat and relevant mass transfer at all scales (nano, micro and macro) and in all types of material (heterogeneous, composites, biological,...) and fluid flow
* Forced, natural or mixed convection in reactive or non-reactive media
* Single or multi–phase fluid flow with or without phase change
* Near–and far–field radiative heat transfer
* Combined modes of heat transfer in complex systems (for example, plasmas, biological, geological,...)
* Multiscale modelling
The applied research topics include:
* Heat exchangers, heat pipes, cooling processes
* Transport phenomena taking place in industrial processes (chemical, food and agricultural, metallurgical, space and aeronautical, automobile industries)
* Nano–and micro–technology for energy, space, biosystems and devices
* Heat transport analysis in advanced systems
* Impact of energy–related processes on environment, and emerging energy systems
The study of thermophysical properties of materials and fluids, thermal measurement techniques, inverse methods, and the developments of experimental methods are within the scope of the International Journal of Thermal Sciences which also covers the modelling, and numerical methods applied to thermal transfer.