Nitro-fatty acid signaling: Therapeutic potential in inflammatory diseases

This review explores the interaction between nitric oxide-derived reactive species and unsaturated fatty acids, leading to the formation of electrophilic nitroalkenes, named nitro-fatty acids (NO₂-FA). These species serve as endogenously produced anti-inflammatory signaling mediators, demonstrating protective effects in pre-clinical animal disease models. The discussion herein focuses on the cell signaling actions of NO₂-FA, drawing insights from both existing knowledge and recent in vivo data. Additionally, this review addresses the potential pharmacological utility of NO₂-FA and ongoing trials, highlighting their promising prospects based on the gathered information.