{"title":"阿尔茨海默氏症患者的特质焦虑与杏仁核及其相关区域的神经胶质相关神经炎症：明显相关","authors":"Fumihiko Yasuno , Yasuyuki Kimura , Aya Ogata , Hiroshi Ikenuma , Junichiro Abe , Hiroyuki Minami , Takashi Nihashi , Kastunori Yokoi , Saori Hattori , Nobuyoshi Shimoda , Atsushi Watanabe , Kensaku Kasuga , Takeshi Ikeuchi , Akinori Takeda , Takashi Sakurai , Kengo Ito , Takashi Kato","doi":"10.1016/j.bbih.2024.100795","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Positron emission tomography, which assesses the binding of translocator protein radiotracers, <sup>11</sup>C-DPA-713, may be a sensitive method for determining glial-mediated neuroinflammation levels. This study investigated the relationship between regional <sup>11</sup>C-DPA713 binding potential (BP<sub>ND</sub>) and anxiety in patients with Alzheimer's disease (AD) continuum.</p></div><div><h3>Methods</h3><p>Nineteen patients with AD continuum determined to be amyloid-/p-tau 181-positive via cerebrospinal fluid analysis were included in this cross-sectional study (mild cognitive impairment [MCI, n = 5] and AD [n = 14]). Anxiety was evaluated using the State-Trait Anxiety Inventory (STAI). A whole-brain voxel-based analysis was performed to examine the relationship between <sup>11</sup>C-DPA-713-BP<sub>ND</sub> values at each voxel and the STAI score. Stepwise multiple regression analysis was performed to determine the predictors of STAI scores using independent variables, including <sup>11</sup>C-DPA-713-BP<sub>ND</sub> values within significant clusters. <sup>11</sup>C-DPA-713-BP<sub>ND</sub> values were compared between patients with AD continuum with low-to-moderate and high STAI scores.</p></div><div><h3>Results</h3><p>Voxel-based analysis revealed a positive correlation between trait anxiety severity and <sup>11</sup>C-DPA713-BP<sub>ND</sub> values in the centromedial amygdala and the left inferior occipital area [<em>P</em> < 0.001 (uncorrected) at the voxel-level]. <sup>11</sup>C-DPA713-BP<sub>ND</sub> values in these regions were a strong predictor of the STAI trait anxiety score. Specifically, patients with AD continuum and high trait anxiety had increased <sup>11</sup>C-DPA713-BP<sub>ND</sub> values in these regions.</p></div><div><h3>Conclusions</h3><p>The amygdala–occipital lobe circuit influences the control of emotional generation, and disruption of this network by AD pathology-induced inflammation may contribute to the expression of anxiety. Our findings suggest that suppression of inflammation can help effectively treat anxiety by attenuating damage to the amygdala and its associated areas.</p></div>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"38 ","pages":"Article 100795"},"PeriodicalIF":3.7000,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666354624000735/pdfft?md5=aef1dfda9e83d8bff04169208c9888b1&pid=1-s2.0-S2666354624000735-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation\",\"authors\":\"Fumihiko Yasuno , Yasuyuki Kimura , Aya Ogata , Hiroshi Ikenuma , Junichiro Abe , Hiroyuki Minami , Takashi Nihashi , Kastunori Yokoi , Saori Hattori , Nobuyoshi Shimoda , Atsushi Watanabe , Kensaku Kasuga , Takeshi Ikeuchi , Akinori Takeda , Takashi Sakurai , Kengo Ito , Takashi Kato\",\"doi\":\"10.1016/j.bbih.2024.100795\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Positron emission tomography, which assesses the binding of translocator protein radiotracers, <sup>11</sup>C-DPA-713, may be a sensitive method for determining glial-mediated neuroinflammation levels. This study investigated the relationship between regional <sup>11</sup>C-DPA713 binding potential (BP<sub>ND</sub>) and anxiety in patients with Alzheimer's disease (AD) continuum.</p></div><div><h3>Methods</h3><p>Nineteen patients with AD continuum determined to be amyloid-/p-tau 181-positive via cerebrospinal fluid analysis were included in this cross-sectional study (mild cognitive impairment [MCI, n = 5] and AD [n = 14]). Anxiety was evaluated using the State-Trait Anxiety Inventory (STAI). A whole-brain voxel-based analysis was performed to examine the relationship between <sup>11</sup>C-DPA-713-BP<sub>ND</sub> values at each voxel and the STAI score. Stepwise multiple regression analysis was performed to determine the predictors of STAI scores using independent variables, including <sup>11</sup>C-DPA-713-BP<sub>ND</sub> values within significant clusters. <sup>11</sup>C-DPA-713-BP<sub>ND</sub> values were compared between patients with AD continuum with low-to-moderate and high STAI scores.</p></div><div><h3>Results</h3><p>Voxel-based analysis revealed a positive correlation between trait anxiety severity and <sup>11</sup>C-DPA713-BP<sub>ND</sub> values in the centromedial amygdala and the left inferior occipital area [<em>P</em> < 0.001 (uncorrected) at the voxel-level]. <sup>11</sup>C-DPA713-BP<sub>ND</sub> values in these regions were a strong predictor of the STAI trait anxiety score. Specifically, patients with AD continuum and high trait anxiety had increased <sup>11</sup>C-DPA713-BP<sub>ND</sub> values in these regions.</p></div><div><h3>Conclusions</h3><p>The amygdala–occipital lobe circuit influences the control of emotional generation, and disruption of this network by AD pathology-induced inflammation may contribute to the expression of anxiety. Our findings suggest that suppression of inflammation can help effectively treat anxiety by attenuating damage to the amygdala and its associated areas.</p></div>\",\"PeriodicalId\":72454,\"journal\":{\"name\":\"Brain, behavior, & immunity - health\",\"volume\":\"38 \",\"pages\":\"Article 100795\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-05-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666354624000735/pdfft?md5=aef1dfda9e83d8bff04169208c9888b1&pid=1-s2.0-S2666354624000735-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain, behavior, & immunity - health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666354624000735\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain, behavior, & immunity - health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666354624000735","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景正电子发射断层扫描可评估转运体蛋白放射性核素11C-DPA-713的结合情况，是确定神经胶质介导的神经炎症水平的灵敏方法。本研究调查了阿尔茨海默病（AD）连续型患者的区域 11C-DPA713 结合电位（BPND）与焦虑之间的关系。方法 本横断面研究纳入了 19 名通过脑脊液分析确定为淀粉样蛋白/p-tau 181 阳性的 AD 连续型患者（轻度认知障碍 [MCI, n = 5] 和 AD [n = 14]）。焦虑采用国家特质焦虑量表（STAI）进行评估。对每个体素的 11C-DPA-713-BPND 值与 STAI 分数之间的关系进行了基于全脑体素的分析。通过使用独立变量（包括重要群组内的 11C-DPA-713-BPND 值）进行逐步多元回归分析，以确定 STAI 分数的预测因素。结果基于象素的分析表明，特质焦虑严重程度与中央内侧杏仁核和左下枕区的 11C-DPA713-BPND 值呈正相关[象素水平上的 P < 0.001（未校正）]。这些区域的 11C-DPA713-BPND 值对 STAI 特质焦虑评分有很强的预测作用。结论杏仁核-枕叶回路影响着对情绪产生的控制，而AD病理诱导的炎症对这一网络的破坏可能会导致焦虑的表达。我们的研究结果表明，抑制炎症有助于减轻杏仁核及其相关区域的损伤，从而有效治疗焦虑症。
Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation
Background
Positron emission tomography, which assesses the binding of translocator protein radiotracers, 11C-DPA-713, may be a sensitive method for determining glial-mediated neuroinflammation levels. This study investigated the relationship between regional 11C-DPA713 binding potential (BPND) and anxiety in patients with Alzheimer's disease (AD) continuum.
Methods
Nineteen patients with AD continuum determined to be amyloid-/p-tau 181-positive via cerebrospinal fluid analysis were included in this cross-sectional study (mild cognitive impairment [MCI, n = 5] and AD [n = 14]). Anxiety was evaluated using the State-Trait Anxiety Inventory (STAI). A whole-brain voxel-based analysis was performed to examine the relationship between 11C-DPA-713-BPND values at each voxel and the STAI score. Stepwise multiple regression analysis was performed to determine the predictors of STAI scores using independent variables, including 11C-DPA-713-BPND values within significant clusters. 11C-DPA-713-BPND values were compared between patients with AD continuum with low-to-moderate and high STAI scores.
Results
Voxel-based analysis revealed a positive correlation between trait anxiety severity and 11C-DPA713-BPND values in the centromedial amygdala and the left inferior occipital area [P < 0.001 (uncorrected) at the voxel-level]. 11C-DPA713-BPND values in these regions were a strong predictor of the STAI trait anxiety score. Specifically, patients with AD continuum and high trait anxiety had increased 11C-DPA713-BPND values in these regions.
Conclusions
The amygdala–occipital lobe circuit influences the control of emotional generation, and disruption of this network by AD pathology-induced inflammation may contribute to the expression of anxiety. Our findings suggest that suppression of inflammation can help effectively treat anxiety by attenuating damage to the amygdala and its associated areas.
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