靶向纳米otheransotics:临床前核磁共振成像和 CT 在晚期疾病分子成像和治疗中的整合。

Q1 Pharmacology, Toxicology and Pharmaceutics
Nanotheranostics Pub Date : 2024-04-23 eCollection Date: 2024-01-01 DOI:10.7150/ntno.95791
Jyoti Bonlawar, Aseem Setia, Ranadheer Reddy Challa, Bhaskar Vallamkonda, Abhishesh Kumar Mehata, Vaishali, Matte Kasi Viswanadh, Madaswamy S Muthu
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引用次数: 0

摘要

临床前磁共振成像(MRI)和计算机断层扫描(CT)方法的整合极大地促进了靶向纳米医学的治疗和成像领域。利用纳米粒子的纳米otheranostics 是 MRI 和 CT 成像的一大进步。除了能同时提供高分辨率的解剖特征和功能信息外,这些多功能制剂在使用时还能提高对比度。除了能实现早期疾病检测、精确定位和个性化治疗监测外,它们还能实现早期疾病检测。核磁共振成像和 CT 的融合可实现对药物负载纳米粒子的体内精确跟踪。核磁共振成像可实时监测纳米粒子在细胞和组织水平的分布、积累和释放情况,可用于评估给药系统的疗效。使用 CT 成像可以实现纳米粒子在体内的精确定位。该技术可提供高分辨率的解剖信息,从而增强核磁共振成像的功能。CT 还能定量测量纳米粒子的浓度,这对评估纳米药物的药代动力学和生物分布至关重要。在这篇文章中,我们强调将临床前核磁共振成像和 CT 整合到晚期疾病的分子成像和治疗中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Targeted Nanotheransotics: Integration of Preclinical MRI and CT in the Molecular Imaging and Therapy of Advanced Diseases.

The integration of preclinical magnetic resonance imaging (MRI) and computed tomography (CT) methods has significantly enhanced the area of therapy and imaging of targeted nanomedicine. Nanotheranostics, which make use of nanoparticles, are a significant advancement in MRI and CT imaging. In addition to giving high-resolution anatomical features and functional information simultaneously, these multifunctional agents improve contrast when used. In addition to enabling early disease detection, precise localization, and personalised therapy monitoring, they also enable early disease detection. Fusion of MRI and CT enables precise in vivo tracking of drug-loaded nanoparticles. MRI, which provides real-time monitoring of nanoparticle distribution, accumulation, and release at the cellular and tissue levels, can be used to assess the efficacy of drug delivery systems. The precise localization of nanoparticles within the body is achievable through the use of CT imaging. This technique enhances the capabilities of MRI by providing high-resolution anatomical information. CT also allows for quantitative measurements of nanoparticle concentration, which is essential for evaluating the pharmacokinetics and biodistribution of nanomedicine. In this article, we emphasize the integration of preclinical MRI and CT into molecular imaging and therapy for advanced diseases.

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来源期刊
Nanotheranostics
Nanotheranostics Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
CiteScore
10.40
自引率
0.00%
发文量
37
审稿时长
12 weeks
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