中性粒细胞--登革热中未被充分研究的旁观者？

IF 14 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-05-14 DOI:10.1016/j.tim.2024.04.011

Caroline Lin Lin Chua, Raika Francesca Morales, Po Ying Chia, Tsin Wen Yeo, Andrew Teo

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引用次数: 0

摘要

登革热是一种由蚊子传播的病毒性疾病，每年都会造成大量的发病和死亡。以往的研究提出了几种致病机制，主要涉及登革热病毒和宿主体液免疫。然而，先天性免疫细胞（如中性粒细胞）也可能在登革热中发挥重要作用，尽管其作用还不那么明确。在这篇综述中，我们讨论了中性粒细胞在登革热中新出现的作用及其在与严重登革热相关的病理中的参与。我们还介绍了几种中性粒细胞蛋白作为重症登革热生物标志物的潜在用途。这些研究表明，中性粒细胞是登革热的重要参与者，因此迫切需要更好地了解中性粒细胞-登革热生物学。

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Neutrophils - an understudied bystander in dengue?

Dengue is a mosquito-borne viral disease which causes significant morbidity and mortality each year. Previous research has proposed several mechanisms of pathogenicity that mainly involve the dengue virus and host humoral immunity. However, innate immune cells, such as neutrophils, may also play an important role in dengue, albeit a much less defined role. In this review, we discuss the emerging roles of neutrophils in dengue and their involvement in pathologies associated with severe dengue. We also describe the potential use of several neutrophil proteins as biomarkers for severe dengue. These studies suggest that neutrophils are important players in dengue, and a better understanding of neutrophil-dengue biology is urgently needed.

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.