2 型糖尿病的根本原因、肠道微生物群和饮食习惯的治疗方案:综述。

Q3 Pharmacology, Toxicology and Pharmaceutics
Krishnendu Adhikary, Riya Sarkar, Sriparna Maity, Ipsita Banerjee, Prity Chatterjee, Koushik Bhattacharya, Deepika Ahuja, Nirmalya Kumar Sinha, Rajkumar Maiti
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引用次数: 0

摘要

2 型糖尿病是一种以持续性高血糖为特征的长期内分泌失调症,通常由胰岛素分泌全部或相对不足或胰岛素抵抗引发。由于胰岛素抵抗(IR)和体内胰岛素的整体缺乏,2 型糖尿病(T2DM)是一种以高血糖为特征的代谢性疾病。值得注意的是,糖尿病血管并发症的发生和 T2DM 中 IR 的发展都伴随着肠道微生物群的失调。糖尿病是一种免疫介导的慢性、进展性疾病,由于其治疗困难和多种并发症的危害,给患者带来了沉重的临床和健康负担。在全球范围内,年轻人患糖尿病的频率和发病率不断上升。肠道微生物群组成与 T2DM 的生理病理特征之间的关系为监测病情和提高治疗效果提供了一种新方法。在过去 20 年中,我们对肠道微生物群及其如何影响健康和疾病的认识发生了变化。在核心动物肠道微生物群中占很大比例的优杆菌属物种是最近发现的可能有用的 "一代 "细菌。在本文中,我们重点讨论了 T2DM 的发病机制和治疗方法,并特别提到了从古至今的肠道细菌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The underlying causes, treatment options of gut microbiota and food habits in type 2 diabetes mellitus: a narrative review.

Type 2 diabetes mellitus is a long-lasting endocrine disorder characterized by persistent hyperglycaemia, which is often triggered by an entire or relative inadequacy of insulin production or insulin resistance. As a result of resistance to insulin (IR) and an overall lack of insulin in the body, type 2 diabetes mellitus (T2DM) is a metabolic illness that is characterized by hyperglycaemia. Notably, the occurrence of vascular complications of diabetes and the advancement of IR in T2DM are accompanied by dysbiosis of the gut microbiota. Due to the difficulties in managing the disease and the dangers of multiple accompanying complications, diabetes is a chronic, progressive immune-mediated condition that plays a significant clinical and health burden on patients. The frequency and incidence of diabetes among young people have been rising worldwide. The relationship between the gut microbiota composition and the physio-pathological characteristics of T2DM proposes a novel way to monitor the condition and enhance the effectiveness of therapies. Our knowledge of the microbiota of the gut and how it affects health and illness has changed over the last 20 years. Species of the genus Eubacterium, which make up a significant portion of the core animal gut microbiome, are some of the recently discovered 'generation' of possibly helpful bacteria. In this article, we have focused on pathogenesis and therapeutic approaches towards T2DM, with a special reference to gut bacteria from ancient times to the present day.

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来源期刊
Journal of Basic and Clinical Physiology and Pharmacology
Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.90
自引率
0.00%
发文量
53
期刊介绍: The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.
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