马吉-卡塔普拉斯通过调节Th1/Th2/Treg/Th17平衡缓解哮喘。

IF 2.5 4区 医学 Q3 ALLERGY
International Archives of Allergy and Immunology Pub Date : 2024-01-01 Epub Date: 2024-05-15 DOI:10.1159/000538597
Yuanjun Liu, Haixia Liu, Qi Shao, Hanfen Shi, Fafeng Cheng, Xueqian Wang
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引用次数: 0

摘要

引言T 细胞在炎症性疾病中起着至关重要的作用。本研究的目的是调查马杰氨肽酶(Majie cataplasm,MJC)对哮喘的影响,并提出参与这一过程的可能机制:方法:检测气道炎症、炎症细胞浸润、白细胞介素 (IL)-4、IL-10、IL-17 和干扰素 (IFN)-γ 水平、Th2、Treg、Th17 和 Th1 细胞水平,以及 IL-4、IL-10、IL-17、IFN-γ、GATA 结合蛋白 3 (GATA-3)、Foxp3、RAR 相关孤儿受体 gamma (RORγt) 和 T-bet 的表达:结果:MJC 治疗降低了肺气道阻力和肺组织中的炎症浸润。结果:MJC 治疗降低了肺气道阻力和肺组织中的炎症浸润,还减少了血液和支气管肺泡灌洗液(BALF)中嗜酸性粒细胞和中性粒细胞的数量。MJC 可抑制血液、BALF 和肺中的 IL-4 和 IL-17 水平,并增加 IFN-γ 和 IL-10。此外,MJC 还能抑制脾细胞中 Th2 和 Th17 的比例,增加 Th1 和 Treg 的比例。此外,MJC 还能通过增加 IFN-γ、IL-10、T-bet 和 Foxp3 的表达,以及减少 IL-4、IL-17、GATA-3 和 RORγt 的表达来抑制哮喘:结论:MJC 可通过调节卵清蛋白诱导大鼠的 Th1/Th2/Treg/Th17 平衡来改善气道高反应性和炎症。结论:MJC 可通过调节卵清蛋白诱导大鼠的 Th1/Th2/Treg/Th17 平衡来改善气道高反应性和炎症,可能是抗哮喘药物的新来源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Majie Cataplasm Alleviates Asthma by Regulating Th1/Th2/Treg/Th17 Balance.

Introduction: T cells play a critical role in inflammatory diseases. The aim of the present study was to investigate the effects of Majie cataplasm (MJC) on asthma and to propose a possible mechanism involved in this process.

Methods: Airway inflammation, infiltration of inflammatory cells, levels of interleukin (IL)-4, IL-10, IL-17, and interferon (IFN)-γ, levels of Th2, Treg, Th17, and Th1 cells, and the expressions of IL-4, IL-10, IL-17, IFN-γ, GATA binding protein 3 (GATA-3), Foxp3, RAR-related orphan receptor gamma (RORγt), and T-bet were detected.

Result: MJC treatment reduced lung airway resistance and inflammatory infiltration in lung tissues. MJC treatment also reduced the numbers of eosinophils and neutrophils in the blood and bronchoalveolar lavage fluid (BALF). The levels of IL-4 and IL-17 in the blood, BALF, and lungs were suppressed by MJC, and IFN-γ and IL-10 were increased. Furthermore, MJC suppressed the percentage of Th2 and Th17 and increased the percentage of Th1 and Treg in spleen cells. In addition, MJC can inhibit asthma by increasing expressions of IFN-γ, IL-10, T-bet, and Foxp3, as well as decreasing expressions of IL-4, IL-17, GATA-3, and RORγt.

Conclusion: MJC may improve airway hyperresponsiveness and inflammation by regulating Th1/Th2/Treg/Th17 balance in ovalbumin-induced rats. And MJC may be a new source of anti-asthma drugs.

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来源期刊
CiteScore
5.60
自引率
3.60%
发文量
105
审稿时长
2 months
期刊介绍: ''International Archives of Allergy and Immunology'' provides a forum for basic and clinical research in modern molecular and cellular allergology and immunology. Appearing monthly, the journal publishes original work in the fields of allergy, immunopathology, immunogenetics, immunopharmacology, immunoendocrinology, tumor immunology, mucosal immunity, transplantation and immunology of infectious and connective tissue diseases.
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