Kensington A Hatcher, Birva K Shah, Mark Burch, Srinivas Sai A Kondapalli, Caroline R Baumal
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引用次数: 0
摘要
背景和目的：在地理萎缩（GA）患者的光学相干断层扫描图像上可观察到视网膜外小管（ORT），但其临床意义尚不清楚。本研究旨在调查 ORT 的发生率及其与 GA 病变生长率的关系：这项事后纵向分析评估了在第二阶段 FILLY 试验中随机接受假治疗的 62 只眼睛。对基线、第 12 个月和第 18 个月的 ORT 患病率进行了估计，并计算了 GA 病变生长率从基线到第 18 个月的变化：结果：在基线、第 12 个月和第 18 个月，ORT 患病率分别为 24%、43% 和 43%。在基线时存在ORT的眼球中，GA病变的平均增长速度在总体人群中以及眼底和非眼底GA亚组中均较慢：结论：ORT的存在可能表明GA病变表型生长较慢，与眼窝受累无关。[眼科手术激光成像视网膜2024;55:XX-XX]。
Background and objective: Outer retinal tubulation (ORT) is observed on optical coherence tomography images from patients with geographic atrophy (GA), but its clinical implications are unclear. The objective of this study was to investigate the prevalence of ORT and its association with GA lesion growth rates.
Materials and methods: This post hoc longitudinal analysis assessed 62 eyes randomized to sham treatment in the phase 2 FILLY trial. ORT prevalence was estimated at baseline, month 12, and month 18 and change in GA lesion growth from baseline to month 18 was calculated.
Results: ORT prevalence rates were 24%, 43%, and 43% at baseline, month 12, and month 18, respectively. Slower mean GA lesion growth was observed in eyes with ORT present at baseline in the overall population as well as the subfoveal and nonsubfoveal GA subgroups.
Conclusion: ORT presence may indicate a slower-growing GA lesion phenotype, independent of foveal involvement. [Ophthalmic Surg Lasers Imaging Retina 2024;55:448-451.].
期刊介绍：
OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.
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