血清维生素 B1 水平长期维持正常与改善心力衰竭患者的预后有关

IF 1.2 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Junko Morimoto, Keisuke Satogami, Takaya Naraoka, Akira Taruya, Atsushi Tanaka
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引用次数: 0

摘要

维生素 B1(VB1)是人体必需的微量营养素,缺乏维生素 B1 会导致心力衰竭(HF)。最近的一项随机对照试验显示,短期补充维生素 B1 未能改善心力衰竭的预后。在本研究中,我们探讨了长期维持血液中正常的 VB1 水平对预防心力衰竭患者不良预后的疗效。患者被分为 3 组:VB1 水平正常且未补充 VB1 的对照组(正常组,n = 25),以及需要短期补充 VB1(短期补充组,n = 25)或长期维持正常血液 VB1 水平(长期维持组,n = 38)的 VB1 缺乏患者。对三组患者首次出现心血管死亡和因心房颤动住院等综合结果的时间进行了比较。63 名(72%)患者出现 VB1 缺乏。卡普兰-梅耶曲线显示,长期维持治疗组的疗效优于其他两组。在多变量分析中,长期维持正常的血液 VB1 水平和年龄是综合预后的独立预测因素。我们的研究结果表明,检测 VB1 缺乏并长期恢复 VB1 水平可能是心房颤动整体治疗策略的一部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-Term Maintenance of Normal Serum Vitamin B1 Levels Is Associated with Better Outcomes in Patients with Heart Failure

Deficiency of vitamin B1 (VB1), an essential micronutrient, causes heart failure (HF). A recent randomized controlled trial failed to show any improvement in HF prognosis after short-term VB1 supplementation. In the current study, we investigated the efficacy of long-term maintenance of normal blood VB1 levels in preventing adverse outcomes in patients with HF.

This study included 88 consecutive patients with HF who received guideline-directed medical therapy at Arida Municipal Hospital. The patients were divided into 3 groups: a control group with normal VB1 levels and no VB1 supplementation (normal group, n = 25), and those presenting with VB1 deficiency, who either required short-term VB1 supplementation (short-term supplementation group, n = 25), or long-term maintenance of normal blood VB1 levels (long-term maintenance group, n = 38). The time to the first appearance of composite outcomes, including cardiovascular death and hospitalization for HF, was compared between the 3 groups.

VB1 deficiency was observed in 63 (72%) patients. The Kaplan-Meier curve showed that the long-term maintenance group had better outcomes than the other 2 groups. In the multivariate analysis, long-term maintenance of normal blood VB1 levels and age were independent predictors of composite outcomes.

VB1 deficiency is frequently observed, and the long-term maintenance of normal blood VB1 levels may result in better outcomes in patients with HF. Our results suggest that the detection of VB1 deficiency and long-term restoration of VB1 levels may be part of the overall therapeutic strategy for HF.

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来源期刊
International heart journal
International heart journal 医学-心血管系统
CiteScore
2.50
自引率
6.70%
发文量
148
审稿时长
6-12 weeks
期刊介绍: Authors of research articles should disclose at the time of submission any financial arrangement they may have with a company whose product figures prominently in the submitted manuscript or with a company making a competing product. Such information will be held in confidence while the paper is under review and will not influence the editorial decision, but if the article is accepted for publication, the editors will usually discuss with the authors the manner in which such information is to be communicated to the reader.
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