Charles Elbar, Benoît Perthame, Andrea Poiatti, Jakub Skrzeczkowski
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引用次数: 0
摘要
组织生长的可压缩模型与流体力学的 Hele-Shaw 自由边界问题之间的联系最近引起了广泛关注。在大多数这些模型中,只考虑了排斥力和平流项。为了考虑长程相互作用,我们加入了表面张力效应,增加了一个非局部项,这导致了退化的非局部 Cahn-Hilliard 方程,并研究了系统的不可压缩极限。退化和源项是主要难题。我们的方法依赖于通过 De Giorgi 迭代获得的新\(L^{\infty }\) 估计值,以及对源项能量的统一控制。我们还利用熵方法证明了任何弱解都能长期收敛到单一恒定的静止状态,即使存在源项也是如此。我们的结果表明,非局部(甚至局部)卡恩-希利亚德方程中的表面张力不会阻止肿瘤完全侵入域。
Nonlocal Cahn–Hilliard Equation with Degenerate Mobility: Incompressible Limit and Convergence to Stationary States
The link between compressible models of tissue growth and the Hele–Shaw free boundary problem of fluid mechanics has recently attracted a lot of attention. In most of these models, only repulsive forces and advection terms are taken into account. In order to take into account long range interactions, we include a surface tension effect by adding a nonlocal term which leads to the degenerate nonlocal Cahn–Hilliard equation, and study the incompressible limit of the system. The degeneracy and the source term are the main difficulties. Our approach relies on a new \(L^{\infty }\) estimate obtained by De Giorgi iterations and on a uniform control of the energy despite the source term. We also prove the long-term convergence to a single constant stationary state of any weak solution using entropy methods, even when a source term is present. Our result shows that the surface tension in the nonlocal (and even local) Cahn–Hilliard equation will not prevent the tumor from completely invading the domain.