Naara Felipe da Fonsêca, José de Oliveira Alves-Júnior, Genil Dantas de Oliveira, Kammila Martins Nicolau Costa, Demis Ferreira de Melo, Pedro José Rolim Neto, Meiry Gláucia Freire Rodrigues, João Augusto Oshiro-Junior
{"title":"青金石/金刚砂-聚环氧乙烷杂化纳米复合材料中 D-葡萄糖的改性释放","authors":"Naara Felipe da Fonsêca, José de Oliveira Alves-Júnior, Genil Dantas de Oliveira, Kammila Martins Nicolau Costa, Demis Ferreira de Melo, Pedro José Rolim Neto, Meiry Gláucia Freire Rodrigues, João Augusto Oshiro-Junior","doi":"10.1007/s10971-024-06387-9","DOIUrl":null,"url":null,"abstract":"<div><p>The aim of this study was to demonstrate the influence of laponite smectite clay on the structural properties and release profile of the ureasil-polyether organic-inorganic hybrid nanocomposite. The sol–gel process was used to synthesize the systems combined with the nano-clay, and three concentrations of D-glucose (3, 5, and 10 wt.%) were analyzed for incorporation. The nanocomposite with the most stable D-glucose concentration was used for the release test. The characterization of the laponite colloidal solution was carried out using different viscosity analyses which showed that the 1.5% proportion was the most suitable for formulation due to the formation of a stable gel. The hybrid membrane characterization techniques using infrared spectroscopy and differential thermal analysis show that the formulation components have no chemical or physical incompatibility with D-glucose; the XRD diffractograms confirm that the crystalline domains of D-glucose are suppressed when incorporated into the amorphous Ureasil-polyether material, indicating complete solubilization in the matrix. Finally, the release results show that 20% of the D-glucose was released in 700 min, with a Korsmeyer-Peppas-type kinetic model. Thus, we can conclude that the nanocomposite developed here showed homogeneity and integrity, with satisfactory and adjustable properties such as its mechanical characteristics and the amount of active release, paving the way for its use in various therapies such as bone regeneration.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":664,"journal":{"name":"Journal of Sol-Gel Science and Technology","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Modified release of D-glucose incorporated into laponite/ureasil–poly(ethylene oxide) hybrid nanocomposite\",\"authors\":\"Naara Felipe da Fonsêca, José de Oliveira Alves-Júnior, Genil Dantas de Oliveira, Kammila Martins Nicolau Costa, Demis Ferreira de Melo, Pedro José Rolim Neto, Meiry Gláucia Freire Rodrigues, João Augusto Oshiro-Junior\",\"doi\":\"10.1007/s10971-024-06387-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The aim of this study was to demonstrate the influence of laponite smectite clay on the structural properties and release profile of the ureasil-polyether organic-inorganic hybrid nanocomposite. 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Finally, the release results show that 20% of the D-glucose was released in 700 min, with a Korsmeyer-Peppas-type kinetic model. 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Modified release of D-glucose incorporated into laponite/ureasil–poly(ethylene oxide) hybrid nanocomposite
The aim of this study was to demonstrate the influence of laponite smectite clay on the structural properties and release profile of the ureasil-polyether organic-inorganic hybrid nanocomposite. The sol–gel process was used to synthesize the systems combined with the nano-clay, and three concentrations of D-glucose (3, 5, and 10 wt.%) were analyzed for incorporation. The nanocomposite with the most stable D-glucose concentration was used for the release test. The characterization of the laponite colloidal solution was carried out using different viscosity analyses which showed that the 1.5% proportion was the most suitable for formulation due to the formation of a stable gel. The hybrid membrane characterization techniques using infrared spectroscopy and differential thermal analysis show that the formulation components have no chemical or physical incompatibility with D-glucose; the XRD diffractograms confirm that the crystalline domains of D-glucose are suppressed when incorporated into the amorphous Ureasil-polyether material, indicating complete solubilization in the matrix. Finally, the release results show that 20% of the D-glucose was released in 700 min, with a Korsmeyer-Peppas-type kinetic model. Thus, we can conclude that the nanocomposite developed here showed homogeneity and integrity, with satisfactory and adjustable properties such as its mechanical characteristics and the amount of active release, paving the way for its use in various therapies such as bone regeneration.
期刊介绍:
The primary objective of the Journal of Sol-Gel Science and Technology (JSST), the official journal of the International Sol-Gel Society, is to provide an international forum for the dissemination of scientific, technological, and general knowledge about materials processed by chemical nanotechnologies known as the "sol-gel" process. The materials of interest include gels, gel-derived glasses, ceramics in form of nano- and micro-powders, bulk, fibres, thin films and coatings as well as more recent materials such as hybrid organic-inorganic materials and composites. Such materials exhibit a wide range of optical, electronic, magnetic, chemical, environmental, and biomedical properties and functionalities. Methods for producing sol-gel-derived materials and the industrial uses of these materials are also of great interest.