基于 MIL-100(Fe)金属有机框架的药物缓释薄膜

IF 1.1 3区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Russian Journal of Coordination Chemistry Pub Date : 2024-05-08 DOI:10.1134/S1070328423600900

A. M. Pak, T. N. Vol’khina, Yu. V. Nelyubina, V. V. Novikov

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引用次数: 0

摘要

摘要在基于明胶、果胶和卡帕卡拉胶的复合薄膜中，将生物相容性金属有机框架 MIL-100(Fe) 用作一种疏水性活性药物成分布洛芬的容器。根据粉末 X 射线衍射和扫描电子显微镜数据，金属有机框架保留了晶体结构，其颗粒均匀地分布在水胶体基质中。利用色谱-质谱分析法对所获得的薄膜材料进行了模拟生物条件测试，结果表明它们可用作缓释活性药物成分的剂型。

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Delayed Drug Release Films Based on MIL-100(Fe) Metal-Organic Framework

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Delayed Drug Release Films Based on MIL-100(Fe) Metal-Organic Framework

Biocompatible metal-organic framework MIL-100(Fe) was used as a container for a model hydrophobic active pharmaceutical ingredient, ibuprofen, in composite films based on gelatin, pectin, and kappa-carrageenan. According to powder X-ray diffraction and scanning electron microscopy data, the metal-organic framework retained the crystal structure and its particles were uniformly distributed throughout the hydrocolloid matrix. Testing of the obtained film materials under simulated biological conditions using chromatography–mass spectrometry analysis showed that they are applicable as a dosage form for slow release of active pharmaceutical ingredients.

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来源期刊

Russian Journal of Coordination Chemistry 化学-无机化学与核化学

CiteScore

2.40

自引率

15.80%

发文量

审稿时长

7.2 months

期刊介绍： Russian Journal of Coordination Chemistry is a journal that publishes reviews, original papers, and short communications on all aspects of theoretical and experimental coordination chemistry. Modern coordination chemistry is an interdisciplinary science that makes a bridge between inorganic, organic, physical, analytical, and biological chemistry.