基于 MIL-100(Fe)金属有机框架的药物缓释薄膜

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-08 DOI:10.1134/S1070328423600900

A. M. Pak, T. N. Vol’khina, Yu. V. Nelyubina, V. V. Novikov

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引用次数: 0

摘要

摘要在基于明胶、果胶和卡帕卡拉胶的复合薄膜中，将生物相容性金属有机框架 MIL-100(Fe) 用作一种疏水性活性药物成分布洛芬的容器。根据粉末 X 射线衍射和扫描电子显微镜数据，金属有机框架保留了晶体结构，其颗粒均匀地分布在水胶体基质中。利用色谱-质谱分析法对所获得的薄膜材料进行了模拟生物条件测试，结果表明它们可用作缓释活性药物成分的剂型。

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Delayed Drug Release Films Based on MIL-100(Fe) Metal-Organic Framework

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Delayed Drug Release Films Based on MIL-100(Fe) Metal-Organic Framework

Biocompatible metal-organic framework MIL-100(Fe) was used as a container for a model hydrophobic active pharmaceutical ingredient, ibuprofen, in composite films based on gelatin, pectin, and kappa-carrageenan. According to powder X-ray diffraction and scanning electron microscopy data, the metal-organic framework retained the crystal structure and its particles were uniformly distributed throughout the hydrocolloid matrix. Testing of the obtained film materials under simulated biological conditions using chromatography–mass spectrometry analysis showed that they are applicable as a dosage form for slow release of active pharmaceutical ingredients.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.