Wen-Xiu Zhu, Yong-Heng Zhao, Peng Zhang, Qing-He Ye, Biao-Fang Wei
{"title":"非创伤性股骨头坏死患者血清丙二醛和超氧化物歧化酶水平：一项横断面研究","authors":"Wen-Xiu Zhu, Yong-Heng Zhao, Peng Zhang, Qing-He Ye, Biao-Fang Wei","doi":"10.1007/s13273-024-00453-7","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objective</h3><p>The present study was aimed to analyze the serum levels of malondialdehyde (MDA) as well as superoxide dismutase (SOD) among patients with non-traumatic (NT) osteonecrosis of the femoral head (ONFH).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Patients with NT-ONFH as well as healthy individuals were selected for this study. MDA and SOD levels in the serum were measured utilizing an enzyme-linked immunosorbent assay (ELISA). Besides, the severity of ONFH was evaluated radiographically utilizing the Ficat classification system. In addition, clinical severity was assessed based on the Harris hip score (HSS)/visual analogue scale (VAS).The clinical methodology for diagnostic use of MDA and SOD with regard to NT-ONFH was determined by decision tree method through R language.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 124 patients with NT-ONFH and 118 healthy individuals were included. NT-ONFH patients exhibited higher MDA levels but lower SOD levels in the serum when compared to healthy controls (HCs) with statistical significance. Among the Ficat stages, stage IV had notably higher MDA levels and lower SOD levels in the serum in contrast with stage III. Additionally, stage III showed increased serum MDA levels and decreased SOD levels in contrast with stage II. MDA levels in the serum in a positive relationship with the Ficat classification, while SOD levels were negatively related to it. Moreover, MDA levels in the serum were in a positive relationship with clinical severity, whereas SOD levels were negatively associated with it. Further analysis using ROC curves indicated that elevated serum MDA levels and reduced SOD levels may serve as favorable markers for assessing Ficat stage.Serum MDA > 0.57 nmol/mL along with SOD ≤ 91.15 U/mL seems to be decent for diagnosis use of NT-ONFH.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Patients diagnosed with NT-ONFH displayed elevated MDA levels and reduced SOD levels in the serum, indicating the involvement of increased oxidative stress and declining antioxidant activity in the progression of this condition.</p>","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"128 1","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum malondialdehyde and superoxide dismutase levels in patients with non-traumatic osteonecrosis of femoral head: a cross-sectional study\",\"authors\":\"Wen-Xiu Zhu, Yong-Heng Zhao, Peng Zhang, Qing-He Ye, Biao-Fang Wei\",\"doi\":\"10.1007/s13273-024-00453-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Objective</h3><p>The present study was aimed to analyze the serum levels of malondialdehyde (MDA) as well as superoxide dismutase (SOD) among patients with non-traumatic (NT) osteonecrosis of the femoral head (ONFH).</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>Patients with NT-ONFH as well as healthy individuals were selected for this study. MDA and SOD levels in the serum were measured utilizing an enzyme-linked immunosorbent assay (ELISA). Besides, the severity of ONFH was evaluated radiographically utilizing the Ficat classification system. In addition, clinical severity was assessed based on the Harris hip score (HSS)/visual analogue scale (VAS).The clinical methodology for diagnostic use of MDA and SOD with regard to NT-ONFH was determined by decision tree method through R language.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>A total of 124 patients with NT-ONFH and 118 healthy individuals were included. NT-ONFH patients exhibited higher MDA levels but lower SOD levels in the serum when compared to healthy controls (HCs) with statistical significance. Among the Ficat stages, stage IV had notably higher MDA levels and lower SOD levels in the serum in contrast with stage III. Additionally, stage III showed increased serum MDA levels and decreased SOD levels in contrast with stage II. MDA levels in the serum in a positive relationship with the Ficat classification, while SOD levels were negatively related to it. Moreover, MDA levels in the serum were in a positive relationship with clinical severity, whereas SOD levels were negatively associated with it. 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Serum malondialdehyde and superoxide dismutase levels in patients with non-traumatic osteonecrosis of femoral head: a cross-sectional study
Objective
The present study was aimed to analyze the serum levels of malondialdehyde (MDA) as well as superoxide dismutase (SOD) among patients with non-traumatic (NT) osteonecrosis of the femoral head (ONFH).
Methods
Patients with NT-ONFH as well as healthy individuals were selected for this study. MDA and SOD levels in the serum were measured utilizing an enzyme-linked immunosorbent assay (ELISA). Besides, the severity of ONFH was evaluated radiographically utilizing the Ficat classification system. In addition, clinical severity was assessed based on the Harris hip score (HSS)/visual analogue scale (VAS).The clinical methodology for diagnostic use of MDA and SOD with regard to NT-ONFH was determined by decision tree method through R language.
Results
A total of 124 patients with NT-ONFH and 118 healthy individuals were included. NT-ONFH patients exhibited higher MDA levels but lower SOD levels in the serum when compared to healthy controls (HCs) with statistical significance. Among the Ficat stages, stage IV had notably higher MDA levels and lower SOD levels in the serum in contrast with stage III. Additionally, stage III showed increased serum MDA levels and decreased SOD levels in contrast with stage II. MDA levels in the serum in a positive relationship with the Ficat classification, while SOD levels were negatively related to it. Moreover, MDA levels in the serum were in a positive relationship with clinical severity, whereas SOD levels were negatively associated with it. Further analysis using ROC curves indicated that elevated serum MDA levels and reduced SOD levels may serve as favorable markers for assessing Ficat stage.Serum MDA > 0.57 nmol/mL along with SOD ≤ 91.15 U/mL seems to be decent for diagnosis use of NT-ONFH.
Conclusions
Patients diagnosed with NT-ONFH displayed elevated MDA levels and reduced SOD levels in the serum, indicating the involvement of increased oxidative stress and declining antioxidant activity in the progression of this condition.
期刊介绍：
Molecular & Cellular Toxicology publishes original research and reviews in all areas of the complex interaction between the cell´s genome (the sum of all genes within the chromosome), chemicals in the environment, and disease. Acceptable manuscripts are the ones that deal with some topics of environmental contaminants, including those that lie in the domains of analytical chemistry, biochemistry, pharmacology and toxicology with the aspects of molecular and cellular levels. Emphasis will be placed on toxic effects observed at relevant genomics and proteomics, which have direct impact on drug development, environment health, food safety, preventive medicine, and forensic medicine. The journal is committed to rapid peer review to ensure the publication of highest quality original research and timely news and review articles.
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